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8/11/2019 ppt respon imun.pptx
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Immune Response
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How does the mecanism
of foreign configuration can cause bothnon specific and specific immune
response?
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Complement
• Complement is a group of protease in a serum
which complement serum’s activity in bacteria
or cell lysis
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CRP (C-reactive Protein)
• An acute phase protein; group of protein
which is increasing in blood when acute
infection happens
• CRP as opsonin to actived classic pathway of
complement
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Cytokine
• Cytokine is group of peptide which is
produced by immunocompetent cell and plays
a role in reducing or increasing immune
system
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Cellular Immune System
• Phagocytes
• NK Cell
•
Lymphocytes
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Phagocytes
• Cells which attract (using chemotaxis),
attached to, swallow, and digest foreign
materials
• Include macrophage
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NK Cell
• NK cell is granular lymphocyte which canrecognize infected surface glycoprotein cell andkill that cell.
•It’s circulating in the blood and lymph to lysecancer cells and virus-infected cells.
• The number of NK cells around 5-5% oflymphocyte in blood and 45% of lymphocyte in
tissues.• These cells have function in nonspecific immunity
against viruses and tumor cells.
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Lymphocytes
• Lymphocytes are cellular components of the
immune system that is specific to the antigen
through receptor structures on the surface of
immunocompetent cells.
• Lymphocytes are divided into two, namely T
and B lymphocytes
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Limfosit T
• it differentiates from thymus gland
• besides as immunocompetent cells, T
lymphocytes also play a role as a regulator in
the bone marrow, whether the body will
respond in humoral or cellular.
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Limfosit B
• It differentiates in Bursa Fabricius for aves and
in gut associated lymphoid tissue (GALT) for
other vertebrates.
• B lymphocytes play a role in humoral immune
system therefore they will be able to
differentiate into plasma cells which can
generate specific antibodies.
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Antibody/Immunoglobulin
• group of glycoprotein which is produced by
plasma cells in response to certain foreign
configuration
• It can bind to the antigen, complement, or
receptors on the surface of
immunocompetent cells
• Antibody can increase the effectivity of
antigen elimination
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How non specific immuneresponse become specific
immune response?
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•Nonspecific immunity acts as first line ofdefense against infectious agent, which
pathogen will be destroyed before it
proliferates and causing infection.• If this defense doesn’t work well, specific
immune system will be activated.
•
Healing through a specific immune responsewill leave specific immunological memory so
that subsequent infection with the same
infectious agent will not cause disease
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Respon Imun
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Trims
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