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Alanine Glycine Cysteine Serine Threonine Tryptophan. Leucine Lysine Phenylalanine Tyrosine Tryptophan. Isoleucine Leucine Tryptophan. Pyruvate. Aspartate Asparagine. Acetyl CoA. Acetoacetyl CoA. Glutamate Glutamine Histidine Proline Arginine. Oxaloacetate. Tyrosine - PowerPoint PPT Presentation
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Citrate
-KetoglutarateSuccinyl CoA
Fumarate
Oxaloacetate
Pyruvate
Acetyl CoA Acetoacetyl CoA
AlanineGlycineCysteineSerineThreonineTryptophan
IsoleucineLeucineTryptophan
GlutamateGlutamineHistidineProlineArginine
LeucineLysinePhenylalanineTyrosineTryptophan
IsoleucineMethionineValine
AspartateAsparagine
TyrosinePhenylalanineAspartate
Classification of Amino Acids
• Amino acids that can form gluconeogenic precursors are called “glucogenic” (pyruvate, -ketoglutarate, succinyl-CoA,
fumarate, or OAA)• Amino acids that form acetyl-CoA or
acetoacetate are called “ketogenic”• Many are BOTH
Glutamate FamilyL-Arginine
Ornithine COO-
H3N-C-H
CH2
CH2
COO-
+
COO-NH
CC C
CH2
H2 H2COO-
H3N-C-H
CH2
CH2
CHO
+COO-
H3N-C-H
CH2
CH2
CH2
+
NH3
L-Histidine L-Glutamine
-Kg Glu
L-ProlineGlutamateSemialdehyde
H2ONH4
+
NAD(P)
H2O
L-Glutamate -Ketoglutarate
L-Phenylalanine
CH2C-COO-H
NH3
HO
L-PhenylalanineCH2C-COO-
H
NH3
CH2-COO-
Phenylpyruvate
CH2C-COO-H
OHPhenyllactate
L-Tyrosine Phenylketonuria CH2C-COO-
O
Phenylacetate
CO2
Pyruvate
Alanine
H2O
Phenylalaninehydroxylase
O2
NADH
CH2C-COO-H
NH3
HO
CH2 C-COO-
O
HO
P. 637
Homogentisate
CH2-COO-
HO OH
H
O
COO-
C=CO=C
CH2 CH2-COO-C
H
C=CH
O
COO-O=C
CH2 CH2-COO-C
H
Fumarate + acetoacetate
Fumarylacetoacetate
Maleylacetoacetate
Oxidized
Homogentisate oxidase
AlcaptonuriaO2
L-TyrosineTyrosine amino transferase
Methionine
Homocysteine
P 630
SHCH2
CH2
H3N-CH-COO-
OHCH2
H3N-CH-COO-
SCH2
CH2
H3N-CHCOO-
CH2
CH COO-
NH3+
Cystathione-lyase CH3
CH2
C=OCOO-
CH2-SHCH COO-
NH3+
+
-Ketobutyrate Cysteine
Cysteine is madefrom Methionine
andMethionine goes to Succinyl CoA
-H2O
Cystathionine
Serine
NH4
+
Propionyl CoA
Succinyl CoA
CH3-C-COO-
+NH3
HAlanine
Cysteine
HS-CH2C-COO-
O
CH3C-COO-
O
-Kg
Glutamate
PyruvateSO42-
Sulfate
[S]
-Mercaptopyruvate
H2S
2RSH
HS-CH2-C-COO-
+NH3
H
O2S-CH2-C-COO-
+NH3
H=
Taurine
CO2
O2
Serine-H2O-NH4
Glycine
O3S-CH2-CH2-NH3+=
p625
-NH4+
Sulfinic acid
HO-CH2-C-COO-
+NH3
H
CH2=C-COO-
+NH3
Serinedehydratase-H2O
CH3C-COO-
OCH3-C-COO-
NH2
NH4
PyruvateH2O
Serine
Requires pyridoxal-5-PO4
Leucine Valine Isoleucine
-C-COO-
OCH
R
R’
-C-CO~SCoAO
CHR
R’
Branch chainaminotransferase
-Keto acid dehydrogenase Complex
(Not in liver)
TPPLipoateFADNAD+
HS-CoA
Maple Syrup Urine Disease