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CONTENTS
Summaries of Chapters e1 to e39 . . . . . . . . . . . . . . . . . . . . . . . . xvii
Contributors . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. xxi
Prefa(e xxxv
-+- PART1I
IntroductiontoClinicalMedicine
1 ThePradi(eof Medicine.. .. .. .... ... .... .. ..... . 1TheEditors
2 610ballssuesin Medicine...... .... ... .. ..... ....... . 6JimYongKim / PaulFarmer
3 Decision-Makingin Clini(alMedicine 16DanielB.Mark
4 S(reening and Prevention of Disease................. 24GaryJ.Martin
5 Principiesof Clini(alPharma(ology.................. 27DanM. Roden
6 Women's Health 39AndreaE.Dunai!
7 Medi(alDisordersduringPregnan(y................. 44RobertL.Barbieri/ JohnT.Repke
8 Medi(alEvaluationof the Surgi(alpatient 49WeiC.Lau/ KimA. Eagle
9 6eriatri( Medicine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
Lisa B. Caruso/ RebeccaA. Silliman
10 Complementary and Alternative Medicine 62StephenE. Straus
11 Palliative and End-of-Life Care 66EzekielJ.Emanuel/ JoshuaHauser / Linda L. Emanuel. e1 TheSafetyandQualityof Health Care ............ elDavid W Bates. e2 E(onomi(Considerationsin the Pradi(e of Medicine. . . . . . . . . . . . . . . . . . . . . . . . .. e7
David Meltzer. e3 Racialand EthnicDisparitiesin Health Care... ... ellJosephR. Betancourt / David Blumenthal. e4 Ethi(allssues in Clini(al Medicine . . . . . . .. . . . . . .. e19BernardLo
-+-. PART2 cardinalManifestations andPresentation of Diseases
_PAIN12 pain:Pathophysiologyand Management 81
HowardL.Fields/ JosephB.Martin13 ChestDis(omfort.. .. . . .. . . .. . . .. . .. . .. .. . .. .. .. 87
Thomas H. Lee
14 Abdominal Pain 91WilliamSilen
15 Heada(he 95PeterJ.Goadsby/ NeilH. Raskin
16 Ba(kand Ne(k Pain... . . .. . . .. . .. . . .. . .. .. .. .. . 107JohnW Engstrom
vii
__ALTERATlONSIN BODY1EMPERATURE
17 Feverand Hyperthermia 117CharlesA. Dinarello / ReuvenPorat
18 Fever and Rash... .. . . . .. .. .. .. . . .. . .. .. .. .. .. . ... 121
Elaine T. Kaye / Kenneth M. Kaye
" e5 Atlasof RashesAssociatedwith Fever e23Kenneth M. Kaye / Elaine T. Kaye
19 Fever of Unknown Origin . . . . . . . . . . . . . . . . . . . . . . . . .. 130
Jeffrey A. Gelfand / Michael V.Callahan
20 Hypothermia and Frostbite. . .. . .. .. .. . . .. . .. .. .. .. 135Daniel F. Danzl.. NERVOUSSYSTEMDYSFUNCTlON
21 Syn(ope.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .139MarkD. Carlson
22 Dizzinessand Vertigo 144RobertB.Daroff
23 Weaknessandparalysis....... .. .... ... ....... .... 147MichaelJ.Aminoff
24 6ait and Balan(e Disorders 151LewisSudarsky
25 Numbness,Tingling,and SensoryLoss 154Michael J.Aminoff / Arthur K. Asbury
26 Confusionand Delirium 158S. Andrew Josephson/ BruceL. Miller
" e6 Memory Loss . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. e33Thomas D. Bird / Bruce L. Miller
27 Aphasia, Memory Loss,andOther Fo(al Cerebral Disorders 162M.-Marsel Mesulam
28 Sleep Disorders.. . .. . . .. . . .. . . .. . .. .. .. . .. .. .. .. .. 171CharlesA. Czeisler/ John W Winkelman /Gary S.Richardson..DISORDERS OF EYES, EARS, NOSE, AND THROAT
29 DisordersoftheEye........................... 180JonathanC.Horton
30 Disordersof Smell,Taste,and Hearing 196Anil K. Lalwani
31 Pharyngitis,Sinusitis,Otitis,andOtherUpperRespiratory Trad Infedions . . . . . . . .. . .. 205MichaelA. Rubin / Ralph Gonzales/ MerleA. Sande
32 OralManifestationsof Disease.. . ... ... 214Samuel C. Durso
" e7 Atlasof OralManifestationsof Disease e37Samuel C. Durso / Janet A. Yellowitz / Jane C. Atkinson..ALTERATlONSIN ClRCULATORYAND RESPIRATORYFUNCTlONS
33 Dyspneaand Pulmonary Edema 221Richard M. Schwartzstein
34 Cough and Hemoptysis . . . . . . . . . . . . . . . . . . . . . . . . . . .. 225Steven E.Weinberger/ David A.Lipson
35 Hypoxia and Cyanosis . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 229Eugene Braunwald
Edema.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 231
EugeneBraunwald / ]osephLosca/zo
e8 Approachto the Patientwith a HeartMurmur .... e43Patrick T.O'Gara / EugeneBraunwald
Palpitations 236]oseph Loscalzo.. ALnRATlONSIN GASTROINTESTlNALFUNCTlON
38 Dysphagia 237Raj K. Goyal
39 Nausea, Vomiting, and Indigestion . . . .. . . . . .. . . . . .. 240William L. Hasler
40 Diarrhea and (onstipation .. .. . . . .. .. . .. . .. . .. . .. . . 245Michael Camilleri / ]oseph A. Murray
41 Weight Loss 255Carol M. Reife
42 Gastrointestinal Bleeding . . . . . . . . . . . . . . . . . . . . . . . . .. 257Loren Laine
43 Jaundice 261Daniel S. Pratt / Marshall M. Kaplan
44 Abdominal Swelling and Ascites 266Robert M. G/ickman / Roshini Rajapaksa
.. ALnRATlONSINRENALANOURINARYTRAOFUNCTlON
45 Azotemia and Urinary Abnormalities. . . . . . . . . . . . . . .. 268Bradley M. Denker / Barry M. Brenner
§ e9 Atlasof UrinarySedimentsand RenalBiopsies... e53Agnes B. Fogo / Eric G. Neilson
46 Fluid and Electrolyte Disturbances . . . . . . . . . . . . . . . . .. 274Gary G. Singer / Barry M. Brenner
47 Hypercalcemia and Hypocalcemia . . . . . . . . . . . . . . . . .. 285Sundeep Khosla
48 Acidosis andAlkalosis. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 287Thomas D. DuBose, Ir... ALnRATlONSIN SEXUALFUNCTIONANO REPROOUCTlON
49 Sexual Dysfunction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 296Kevin T. McVary
SO Hirsutism and Virilization 301David A. Ehrmann
51 Menstrual Disorders and Pelvic Pain 304]anet E. Hall_ ALnRATlONSINTHESKIN
52 Approach to the Patient with a Skin Disorder. . . . . . .. 308Thomas /. Lawley / Kim B. Yancey
53 Eczema,Psoriasis,(utaneous Infections,Acne,and Other(ommon skin Disorders. 312Calvin O. McCall / Thomas ]. Lawley
54 SkinManifestationsof InternalDisease. . . . . .. . . . . . . 321]ean L. Bolognia /lrwin M. Braverman
SS ImmunologicallyMediatedSkinDiseases . . . . . . . . . .. 336Kim B. Yancey / Thomas ]. Lawley
56 (utaneous Drug Reactions .. .. .. .. .. .. .. .. .. .. .. ... 343]ean-Claude Roujeau / Robert S. Stern / Bruce U. Wintroub
57 Photosensitivity and Other Reactions to Light . .. . . .. 350David R. Bickers
e10 Atlas of Skin Manifestationsof Internal Disease e61Thomas ]. Lawley/ Stephen F.Templeton_ HEMATOLOGICALnRATlONS
58 Anemiaand Polycythemia 355]ohn w: Adamson / Dan L. Longo
59 Bleeding and Thrombosis. . . . . . . . . . . . . . . . . . . . . . . . .. 363BarbaraA. Konkle
60 Enlargement ofLymphNodesandSpleen 370PatrickH. Henry / Dan L. Longo
61 Disordersof Granulocytesand Monocytes 375Steven M. Holland / ]ohn 1. Gallin
§ e11 Atlasof Hematologyand Analysisof PeripheralBloodSmears e77Dan L. Longo
~ PART3 Geneticsand Disease
62 Principies of Human Genetics . . . . . . . . . . . . . . . . . . . . .. 385]. Larry]ameson/ PeterKopp
63 (hromosomeDisorders 407Terry]. Hassold/ Stuart Schwartz
64 ThePracticeof Geneticsin (linical Medicine .. .. 414
Susan Miesfeldt/ ]. Larry]ameson
65 GeneTherapyin(linicalMedicine 420KatherineA. High
-.- PART4 Regenerative MedicineI
66 Stem (en Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 425
Minoru S.H.Ko
67 Applicationsof Stem(en Biologyin (Iinical Medicine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 427
]ohn A. Kessler
68 HematopoieticStem(ens .. . . . . . . . . . . . . . . . . . . . . . .. 430David T. Scadden / Dan L. Longo
69 Tissue Engineering 434]ennifer Anderson / ]oseph P. Vacanti
-~ PART S Nutrition
viii 36
§
37
70 NutritionalRequirementsand DietaryAssessment... 437]ohannaDwyer
71 Vitamin and TraceMineralDeficiency and Excess.. .. .. .. . .. .. .. .. . . .. .. . .. ... 441RobertM. Russell/ PaoloM. Suter
72 Malnutritionand NutritionalAssessment........... 450
DouglasC.Heimburger73 Enteral and parenteral Nutrition Therapy ........... 455
Bruce R.Bistrian / David F.Driscoll
74 Biology of Obesity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 462]effreyS.Flier/ EleftheriaMaratos-Flier
75 Evaluation and Management of Obesity ............ 468RobertF.Kushner
76 Eating Disorders.................................. 473B. Timothy Walsh
~ PART6 Oncologyand Hematology.. NEOPLASTlCDISORDERS
77 Approach to the Patient with Cancer . . . . . . .. . . . . . .. . 479Dan 1. Longo
78 prevention and Early Detedion of Cancer. . . . . . . . . . . . 486Oris \-v.Brawley / Barnett S. Kramer
79 CancerGenetics .. ... .. .. .... ... .... .. ... .. .. ...... 492Pat J.Morin / Jeffrey M. Trent / Francis S. Collins /
Bert Vogelstein
80 Cancer Cell Biology and Angiogenesis 498RobertG.Fenton/ Dan 1. Longo
81 Principiesof CancerTreatment... . .. . ... . ... ... 514EdwardA. Sausville/ Dan 1. Longo
82 Infedions in Patients with Cancer . . . . . . . . . . . . . . . . .. 533
Robert Finberg
83 Cancerofthe 5kin.. .. .. .. .. . .. .. . .. . .. .. .. .. .. . . .. 541Arthur J. Sober / Hensin Tsao / Carl V. Washington
84 Head and Neck Cancer.. .. .. .. . .. . .. . .. .. .. . . .. . . .. 548
Everett E. Vokes
85 Neoplasmsof the Lung.. .. .. .. .. . .. . . .. . .. . . .. . . .. 551JohnD. Minna / Joan H. Schiller
86 BreastCancer 563Marc E.Lippman
87 Gastrointestinal Trad Cancer . . . . . . . . . . . . . . . . . . . . . . . 570
RobertJ.Mayer
88 Tumors of the Liver and Biliary Tree.. . . . . . . . . . . . . . .. 580Brian1.Carr
89 PancreaticCancer 586YuJoChua/ DavidCunningham
90 Bladder and Renal CellCarcinomas ................. 589Howard1.Scher/ RobertJ.Motzer
91 BenignandMalignantDiseasesof the Prostate 593Howard1.Scher
92 Testicular Cancer .. .. ... . .. . . .. .. . .. . .. . . .. . . .. . . .. 601
Robert J.Motzer / George J.Bosl
93 GynecologicMalignancies 604RobertC.Young
94 50ftTissueandBone5arcomasand Bone Metastases .. .. .. .. .. .. . .. . .. . . .. . . .. . .. . 610
ShreyaskumarR.Patel/ RobertS.Benjamin
95 Carcinomaof UnknownPrimary 614GauriR.Varadhachary/ James1.Abbruzzese
96 Paraneoplastic 5yndromes:EndocrinologicjHematologic 617J.LarryJameson/ BruceE.Johnson
97 Paraneoplastic Neurologic 5yndromes. . . . . . . . . . . . . . . 623
JosepDalmau/ MyrnaR.Rosenfeld
fI e12 Thymoma e89Dan1.Longo
fI e13 LateConsequences of Cancerand Its Treatment . .. . .. .. .. . . .. .. .. .. . .. .. . .. . .. . . e91
MichaelC.Perry/ Dan1.Longo..HEMATOPOIETICDISORDERS
98 IronDeficiency and OtherHypoproliferative Anemias 628John\-v.Adamson
.. DISORDERSOFHEMOSTASIS
109 Disorders of Platelets and Vessel Wall ... . . . . . . . . . .. 718Barbara A. Konkle
110 Coagulation Disorders . .. . .. . . .. . .. . . .. . . .. . .. .. ... 725
Valder Arruda / Katherine A. High
111 Venous Thrombosis . . . . . . .. . . .. . .. . . .. . . . .. .. . . ... 731
F.R. Rosendaal / H.R. Büller
112 Antiplatelet,Anticoagulant,and Fibrinolytic Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 735
Jeffrey 1. Weitz
-+ PART7 Infectious Diseases_ RASICCONSIDERATlONSIN INFEalOUSDISEASES
113 Introdudionto InfectiousDiseases:Host-PathogenInteradions 749LawrenceC.Madoff/ Dennis1.Kasper
114 MolecularMechanismsof MicrobialPathogenesis ... 753GeraldB.Pier
115 Approach to the Acutely JIIInfeded FebrilePatient .. .... .... ... .... .... 761
Tamar F.Barlam / Dennis 1. Kasper
116 Immunization Principies and Vacdne Use 767Gemid T. Keusch / Kenneth /. Bart / Mark Miller
117 Health Advice for International Travel .. . ... .... 782JayS. Keystone / Phyllis E. Kozarsky
" e14 LaboratoryDiagnosisof Infedious Diseases e97Alexander J. McAdam / Andrew B. Onderdonk..CLlNICALSYNDROMES:COMMUNITY-ACQUIREDINFEalONS
118 Infedive Endocarditis. . . .. . .. . . .. . .. .. . .. .. . . .. ... 789
Adolf\-v. Karchmer
99 Disorders of Hemoglobin . . . . . . . . . . . . . . . . . . . . . . . . .. 635 ixEdward J.Benz, Jr.
100 Megaloblastic Anemias ........................... 643A. VictorHoffbrand
101 Hemolytic Anemias and .AnemiaDue to Acute Blood Loss . . . . . . . . . . . . . . . . . . . . . . . . . .. 652
Lucio Luzzatto
102 Aplastic Anemia, Myelodysplasia, and RelatedBone Marrow Failure 5yndromes . . . . . . . . . . . . . . . . . .. 663
Neal S. Young103 Polycythemia Vera and Other
Myeloproliferative Diseases ....................... 671Jerry 1. Spivak
104 Acute and ChronicMyeloid Leukemia .............. 677Meir Wetzler/ John C. Byrd / ClaraD. Bloomfield
105 Malignancies of Lymphoid Cells . . . . . . . . . . . . . . . . . . .. 687Dan 1. Longo
106 plasma Cell Disorders ............................. 700Nikhil C. Munshi / Dan 1. Longo/ Kenneth C.Anderson
107 Transfusion Biology and Therapy . . . . . . . . . . . . . . . . . .. 707JefferyS. Dzieczkowski/ Kenneth C.Anderson
108 HematopoieticCellTransplantation... ... . ... . .. . ... 713FrederickR. Appelbaum
.. DlSEASESCAUSEDBYGRAM-POSITlVEBACTERIA
128 Pneumococcallnfections o .. o . .. .. .. oo .. .. o.. 865Daniel M. Musher
129 Staphylococcallnfections.. o. ooo.. o oo. o 0.872Franklin D. Lowy
130 Streptococcal and Enterococcallnfections . . . . . . . . . o. 881Michael R. Wessels
131 Diphtheria and Other Infections Causedby Corynebacteria and Related Species . o. . . . o. . o. . o 890William Ro Bishai / John R. Murphy
132 InfectionsCausedbyListeriomonocytogeneso. . oo. o 895Elizabeth 1. Hohmann / Daniel Ao Portnoy
133 Tetanus o. oo. oooo. o. o. o.. o. .. o.. .. o.. o... o... ... .. 898
Elias Abrutyn
134 Botulismo.ooooooo . oo. . oo . . o. . o . . oo. oo . o. . . o . . o. . o. 901
Elias Abrutyn
135 Gas Gangrene and Other Clostridiallnfections . . . . . .. 903
Dennis L. Kasper / Lawrence C. Madoff_ DISEASESCAUSEDBYGRAM-NEGATlVEBACTERIA
136 Meningococcallnfections o. . o. . . . . o. . . o. . . . . . . . . . .. 908Lee Mo Wetzler
137 Gonococcallnfections.. o ... o.. ... .. . . o. ... . .. o 914Sanjay Ram / Peter Ao Rice
138 Moroxello Infections .. o.. . o.. .. . .. .. . .. .. .. .. . . ... 921Daniel M. Musher
139 Hoemophilus Infections . . .. .. . .. .. o.. oo.. o.. o.. oo. 923Timothy F. Murphy
140 Infections Due to the HACEKGroup andMiscellaneousGram-NegativeBacteria . o o o o o . o o o o o. 926Tamar F. Barlam / Dennis L. Kasper
..MISCELLANEOUS BACTERIALINFECTlONS
155 Nocardiosis oo .. . o 992Gregory A. Filice
156 Actinomycosisoo.. o.. . o.. o.. . .. oo.. .. . .. . oo.. .. ooo 996Thomas A. Russo
157 Infections Due to Mixed Anaerobic Organisms oo.. . o 999
Dennis L. Kasper / Ronit Cohen-Poradosu.. MYCOBACTERIALDISEASES
158 Tuberculosis o.. o.. o.. . .. o. . . ... 1006
Mario C. Raviglione / Richard]. O'Brien
159 leprosy (Hansen's Disease) 1021Robert H. Gelber
160 NontuberculousMycobacteria.. oo .. o .. oo. oo. ooo.. 1027C. Fordham von Reyn
161 Antimycobacterial Agents. o.. o o 1032Richard J. Wallace, Jro/ David E. Griffith_ SPIROCHETALDISEASES
162 Syphilis. o. . . o. . oo. o. . oo. oo. oooo. oo. oo. oo. . . o. . .. 1038Sheila A. Lukehart
163 EndemicTreponematoses. o.. o.. . oo.. o.. o.. . . .. .. 1046Sheila A. Lukehart
164 leptospirosis o .. oo .. oo .. o .. o .. o .. o .. o .. oo .. oo 1048Peter Speelman / Rudy Hartskeerl
165 Relapsing Fever 1052David T. Dennis
x 119 Infections of the Skin, Musde, and Soft Tissues o. . o . o 798 141 Legionello Infection o o o o o o . o o o o . o o o . . o o o . o o o . o o . . o 929Dennis 1. Stevens Miguel Sabria / Victor 1. Yu
120 Osteomyelitis . . . . . . . . . . . . . . . . . . . . . . o. . oo. oo. oo. ooo 803 142 PertussisandOther Bordetello Infections . ooo. . oo. o 933
Jeffrey Parsonnet Scott Ao Halperin
121 Intraabdominallnfections and Abscesses . . o. . o. . . .. 807 143 Diseases Causedby Gram-NegativeEntericBacillio . o 937Miriam JoBaron / Dennis L. Kasper Thomas Ao Russo / James RoJohnson
122 Acute Infectious Diarrheal Diseases 144 HelicobocterpyloriInfections . o o o o o . o o o . o o o o . . o o .. 946andBacterialFoodPoisoningo o . . o o . o o o o o . o o . o o . o o. 813 John C. Atherton / Martin J. Blaser
Joan R. Butterton / Stephen B. Calderwood 145 Infections Due to Pseudomonos Species123 Clostridium difficile-Associated Disease, and Related Organisms . o. . o. . . . . . . . . o. . . . . . o. o. .. 949
Induding pseudomembranous Colitiso o. o o. o o. o o. o o. 818 Reuben RamphalDale No Gerding / Stuart Johnson 146 Salmonellosis ooo. oo . oo. oo . . . . oo. . oo . . . . . . . . . . . . .. 956
124 Sexually Transmitted Infections: David A. Pegues / Samuel 1. MillerOverview and ClinicalApproach . . o. . . o. . . . . o. . o. ooo 821 147 Shigellosis . oo. oo. oo. . . o. . . oo. . . . . . o. . . . . . . . . . . . .. 962King KoHolmes Philippe Sansonetti / Jean Bergounioux
G e15 InfectiousComplicationsof BurnsandBiteso. o e107 148 Infections Due to CompylobocterLawrence C. Madoff / Florencia Pereyra and Related Species ............. o.. .. o.. o.. .. oooo 965.. CLlNICAL SYNDROMES: HEALTH CARE-ASSOCIATEDINFECTIONS
Martin JoBlaser
149 Cholera and Other Vibrioses .. .. .. o.. .. o.. .. oo.. ooo 968
125 Health Care-Associated Infections . ooo . oooo . . o. . o . . o 835Matthew K. Waldor / Gerald T. Keusch
Robert A. Weinstein 150 Brucellosis . o . . oo. . oooo. . oo . . oo. ooo. o . . . . o . oooo . .. 973
126 Infections in Transplant Recipients ooo . oo. oo . o. . o . . o 842Michael]. Corbel / Nicholas JoBeeching
Robert Finberg / Joyce Fingeroth 151 Tularemia o . oo. ooo . . . . . . . o . . . . . . . o. o . oooo . . ooooooo 976
Richard F. Jacobs / Gordon E. Schutze.. APPROACHTOTHERAPYFORBACTERIALDISEASES 152 Plague and Other Yersinio Infections . . . . o. o. o. . . oo. 980David T. Dennis / Grant L. Campbell
127 Treatmentand Prophylaxisof Bacteriallnfectionso.. 851 153 Bortonello Infections, IndudingGordon L. Archer / Ronald EoPolk Cat-Scratch Disease .. . . . . . . o. . o. . oo. o. . o. . ooo. ooo. 987
David H. Spach / Emily Darby
154 Donovanosis oo. oo. o. . . . . . . . . . . . . . . . . . . . . . . . ooo. . o 991Gavin Hart
166 LymeBorreliosis 1055Al/enC.Steere_OISEASESCAUSEOBYRICKETTSIAE,
~ MYCOPLASMAS,ANOCHLAMYOIAE
167 Rickettsial Diseases 1059
David H. Wa/ker / J.Stephen Dum/er / Thomas Marrie
168 Infections Due to Myeoplasrnas 1068Wil/iam M. McCormack
169 Chlarnydiallnfections 1070Wa/ter E. Stamm
__ VIRAL OISEASES: GENERAL CONSIOERATIONS
170 MedicalVirology.. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ... 1079PredWang/ El/iottKieff
171 AntiviralChernotherapy,ExcludingAntiretroviralDrugs . . . . . . . . . . . . . . . . . . . .. 1087LindseyR. Baden / Raphae/Do/in__ INfECTIONSOUETOONAVIRUSES
172 HerpesSimplexViruses..... . .. . ... . ... . ... ... 1095Lawrence Corey
173 Varicella-IosterVirusInfections 1102Richard J.Whit/ey
174 Epstein-BarrVirusInfections,Including Infectious Mononucleosis. . . . . . . . . . . . . . .. 1106Jeffrey 1. Cohen
175 Cytomegalovirusand HurnanHerpesvirusTypes6, 7, and 8 .... ... ... .. ... .. .. .. 1109Martin S.Hirsch
176 MolluscumContagiosum,Monkeypox,andOtherPoxviruses,ExcludingSmallpoxVirus . . . . . . .. 1113PredWang
177 Parvovirus Infections . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1114
KevinE.Brown
178 HumanPapillomavirusInfections 1117RichardC.Reichman_ INfEalONSOUETOONAANORNARESPIRATORYVIRUSES
179 Common Viral Respiratory Infections andSevereAcuteRespiratorySyndrome(SARS) 1120Raphae/ Do/in
180 Influenza 1127
Raphae/ Do/in_ INfECTIONSOUETOHUMANIMMUNOOEflCIENCY~ VIRUSANOOTHERHUMANRETROVIRUSES
181 The Human Retroviruses . . . . . . . . . . . . . . . . . . . . . . . . .. 1132
Dan 1. Longo / Anthony S. Pauci
182 Human Immunodeficiency Virus Disease:AIDS and Related Disorders .. . . . . . . . . . . . . . . . . . . . .. 1137
Anthony S. Pauci / H. C/ifford Lane
__ INfECTIONSOUETORNAVIRUSES
183 Viral Gastroenteritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1204
Umesh D. Parashar / Roger 1. G/ass
184 Enterovirusesand Reoviruses.. . ... ... . ... ... 1208
Jeffrey 1. Cohen
185 Measles(Rubeola) . ... . .. . . . ... . .Anne Gershon
186 Rubella(GermanMeasles).......................Anne Gershon
187 Mumps.........................................Anne Gershon
188 Rabiesand OtherRhabdovirusInfections. . . . . . . . . .A/an C. Jackson / Eric C. Johannsen
189 Infections Caused by Arthropod-and Rodent-Borne Viruses . . . . . . . . . . . . . . . . . . . . . . . .Clarence J.Peters
190 Ebola and Marburg Viruses. . . . . . . . . . . . . . . . . . . . . . . .C/arence J. Peters_ fUNGALANOALGALINfEalONS
191 Diagnosisand Treatmentof Fungallnfections 1242John E. Edwards, Jr.
192 Histoplasmosis 1244ChadiA. Hage/ 1. JosephWheat
193 Coccidioidomycosis 1247Nei/ M. Ampe/
194 Blastomycosis 1249Stan/ey W Chapman / Donna C. Sul/ivan
195 Cryptococcosis 1251Arturo Casadeval/
196 Candidiasis 1254John E. Edwards, Jr.
197 Aspergillosis 1256David W Denning
198 Mucormycosis 1261A/an M. Sugar
199 MiscellaneousMycosesandAlgallnfections 1263Stan/ey W Chapman / Donna C. Sul/ivan
200 Pneumocystis Infection 1267A. George Smu/ian / Peter D. Wa/zer.. PROTOZOALANO HELMINTHICINfEalONS:
GENERALCONSIDERATIONS
§ e16 Laboratory Diagnosis of Parasitie Infections ... .e113Sharon 1. Reed / Charles E. Davis
201 Agents Usedto TreatParasiticInfections 1270Thomas A. Moore
e17 Pharmacology ofAgents Usedto TreatParasitic Infections .e119ThomasA. Moore_ PROTOZOALINfECTlONS
202 AmebiasisandInfectionwith Free-LivingAmebas... 1275Sharon L. Reed
203 Malaria 1280
Nicho/as J. White / Joe/ G. Breman
204 Babesiosis 1294JeffreyA. Gelfand/ Edouard Vannier
§ e18 Atlasof BloodSmearsof MalariaandBabesiosis. .e127Nicho/as J.White / Joe/ G. Breman
205 Leishmaniasis 1296Barbara 1. Herwa/dt
206 Trypanosomiasis 1300Louis V.Kirchhoff
1214 xi
1217
1220
1222
1226
1240
xii 207 ToxoplosmoInfections 1305Lloyd H. Kasper
208 Protozoallntestinallnfectionsand Trichomoniasis... 1311Peter F. Weller_ HELMINTHICINFECTlONS
209 Trichinelloand OtherTissueNematodes ... 1316Peter F. Weller
210 IntestinalNematodes 1319Peter F. Weller / Thomas B. Nutman
211 Filarial and Related Infections 1324
Thomas B. Nutman / Peter F. Weller
212 schistosomiasisand OtherTrematodeInfections ... 1330Adel A. F.Mahmoud
213 Cestodes 1336A. Clinton White, Jr. / Peter F. Weller
-.- PART8I
BioterrorismandClinicalMedicine
214 MicrobialBioterrorism 1343
H. CliffordLane / Anthony S.Pauci215 ChemicalBioterrorism.. ... . ... .. ... ... ... 1352
Charles G. Hurst / Jonathan Newmark /James A. Romano,Jr.
216 Radiation Bioterrorism.. . .. ... . ... ... . .. . .. 1358
Zelig A. Tochner / Eli Glatstein
-+- PART9 DisordersofthecardiovascularSystem.. INTRODUCTlONTOCARDIOVASCULARDISORDERS
217 Basic Biology of the Cardiovascular System 1365Joseph Loscalzo/ PeterLibby/ EugeneBraunwald
218 Epidemiologyof CardiovascularDisease 1375Thomas A. Gaziano / J. Michael Gaziano
219 Approach to the patient withPossible Cardiovascular Disease . . . . . . . . . . . . . . . . . .. 1379
EugeneBraunwald.. DIAGNOSISOFCARDIOVASCULARDISORDERS
220 Physical Examination of theCardiovascular System . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1382
RobertA. O'Rourke/ EugeneBraunwald
221 Electrocardiography.. .. . . . . .. . . . . . .. . . . . . .. . . . . .. 1388Ary L. Goldberger
§ e19 Atlasof Electrocardiography.... .. . .. . ... ... .. .e131Ary L. Goldberger
222 Noninvasive Cardiac Imaging: Echocardiography,NuclearCardiology,and MRI/CTImaging 1397Rick A. Nishimura / Raymond J. Gibbons /JamesF. Glockner/ A. Jamil Tajik
§ e20 Atlasof NoninvasiveCardiacImaging .e149Rick A. Nishimura / Raymond J. Gibbons /
James F. Glockner / A. Jamil Tajik
223 Diagnostic Cardiac Catheterizationand Angiography 1405Donald S.Baim
_ DISORDERSOFRHYTHM
224 Principiesof Electrophysiology 1410GordonF.Tomaselli
225 TheBradyarrhythmias 1416GordonF.Tomaselli
226 TheTachyarrhythmias 1425Prancis Marchlinski
§ e21 Atlasof CardiacArrhythmias... . ... . .. ... e159Ary L. Goldberger.. DISORDERSOFTHEHEART
227 Heart Failureand CorPulmonale .................. 1443
DouglasL.Mann
228 CardiacTransplantationandprolongedAssistedCirculation.. ... . ... . . 1455Sharon A. Hunt
229 Congenital Heart Diseasein the Adult 1458John S. Child
230 Valvular Heart Disease . . . . . . . . . . . . . . . . . . . . . . . . . .. 1465
Patrick O'Gara / Eugene Braunwald
231 Cardiomyopathyand Myocarditis.. . . . . . . . . . . . . . . .. 1481Joshua Wynne / Eugene Braunwald
232 pericardialDisease 1488Eugene Braunwald
233 Tumors and Trauma of the Heart 1495Eric H. Awtry / Wilson S. Colucci
234 CardiacManifestationsof SystemicDisease. . . . . . .. 1498Eric H. Awtry / Wilson S. Colucci..VASCULAR DISEASE
235 The Pathogenesis,Prevention,and Treatment of Atherosclerosis . . . . . . . . . . . . . . . .. 1501
PeterLibby
§ e22 Atlas of Atherosclerosis e171PeterLibby
236 TheMetabolicSyndrome. .. . . .. . .. . . .. . . .. . .. . . .. 1509Robert H. Eckel
237 IschemicHeart Disease 1514
Elliott M. Antman / Andrew P.Selwyn /EugeneBraunwald / JosephLoscalzo
238 Unstable Angina and Non-ST-ElevationMyocardiallnfarction 1527Christopher P.Cannon / EugeneBraunwald
239 ST-SegmentElevationMyocardiallnfarction 1532ElliottM. Antman / EugeneBraunwald
240 PercutaneousCoronaryIntervention. . . . . .. . . . . . .. 1544Donald S. Baim
e23 Atlas of PercutaneousRevascularization e173Donald S.Baim
Hypertensive Vascular Disease. . . .. . . . . . .. . . . . . . .. 1549Theodore A. Kotchen
242 Diseasesof theAorta .. . . . . . . . . . . . . . . . . . . . . . . . . .. 1563Mark A. Creager/ JosephLoscalzo
243 VascularDiseasesof the Extremities 1568Mark A. Creager / Joseph Loscalzo
244 PulmonaryHypertension 1576Stuart Rich
241
~ PART1O Disordersof the~ RespiratorySystem.. DIAGNOSISOFRESPIRATORYDISORDERS
245 Approachto the PatientwithDiseaseof the Respiratory System . . . . . . . . . . . . . . . .. 1583
David A. Lipson / StevenE. Weinberger
246 Disturbancesof Respiratory Function 1586StevenE. Weinberger/ llene M. Rosen
247 Diagnostic procedures inRespiratory Disease 1593SeottManaker / StevenE. Weinberger
ti e24 Atlas of Chestlmaging ... .. .. .... .... .. .. .. .. e179Patricia A. Kritek / JohnJ.Reilly, Jr... DISEASESOFTHERESPIRATORYSYSTEM
248 Asthma .. .. .. . .. .. . .. . .. . . .. . . .. . .. . . .. . .. . . .. . .. 1596
PeterJ.Barnes
249 Hypersensitivity Pneumonitis andPulmonary Infiltrates with Eosinophilia . . . . . . . . . . .. 1607
JoelN. Kline / Gary W Hunninghake
250 Environmental Lung Disease ... . . . . . .. . . . . . .. . . . .. 16Il
Prank E. Speizer/ JohnR. Balmes
251 Pneumonia 1619LionelA. Mandell / Riehard Wunderink
252 Bronchiectasisand Lung Abscess .................. 1629GregoryTino / StevenE. Weinberger
253 Cystic Fibrosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1632Riehard C. Boueher
254 Chronic Obstructive Pulmonary Disease . . . . . .. . . . .. 1635
JohnJ.Reilly,fr. / Edwin K. Silverman /StevenD. Shapiro
255 Interstitial Lung Diseases .. ... .... ... ... .... .... .. 1643TalmadgeE.King, Jr.
256 Deep Venous Thrombosis andpulmonary Thromboembolism ... ... .... .... .. 1651Samue/Z. Goldhaber
257 Disordersof the Pleura and Mediastinum . . . . .. . . .. 1658
Riehard W Light
258 Disorders of Ventilation . . .. . .. .. .. . . .. . . .. .. .. . ... 1661
Eliot A. Phillipson
259 SleepApnea ... .. .. .... .... ... .... ... 1665Neil J.Douglas
260 LungTransplantation .. ... ... .. .. .... ... .... ... ... 1668Elbert P.Truloek.PART11 CriticalCareMedicine
I.. RESPIRATORYCRITlCALCARE
261 Principiesof CriticalCareMedicine.. ... . ... 1673JohnP.Kress/ fesseB. Hall
262 Acute Respiratory Distress Syndrome 1680BrueeD. Levy / StevenD. Shapiro
263 Mechanical Ventilatory Support 1684EdwardP.lngenito
.. SHOCKANDCARDIACARREST
264 Approach to the Patient with Shock. . . . .. . . . . . .. .. 1689Ronald V. Maier
265 Severe Sepsis and Septic Shock. . . . . . . . . . . . . . . . . . .. 1695
Robert S. Munford
266 Cardiogenic shock and pulmonary Edema 1702Judith S.Hoehman / David H. lngbar
267 Cardiovascular Collapse, Cardiac Arrest,and Sudden (ardiac Death . . . . . . . . . . . . . . . . . . . . . . .. 1707
Robert J.Myerberg / Agustin Castellanos
xiii
.. NEUROLOGICCRITlCALCARE
268 Coma 1714
Allan H. Ropper
269 Neurologic Critical Care, IndudingHypoxic-Ischemic Encephalopathyand Subarachnoid Hemorrhage 1720J. Claude Hemphill III / Wade S. Smith..ONCOLOGICEMERGENCIES
270 Oncologic Emergencies .. . .. . . .. . .. . .. . . . .. .. .. ... 1730Rasim Guealp / Janiee P. Duteher. PART12
IDisordersof the Kidneyand UrinaryTract
271 Cellularand MolecularBiologyof the Kidney 1741Alfred L. George, Jr. / Erie G. Neilson
272 Adaptationof the Kidneyto Renallnjury .... .... .. 1748Raymond C. Harris / Erie G. Nei/son
273 Acute Renal Failure . . .. . . .. . .. . . .. . .. . . .. . . .. . ... 1752
Kathleen D. Liu / Glenn M. Chertow
274 Chronic Kidney Disease... .. .. . . .. . .. .. .. . . .. . . ... 1761
Joanne M. Bargman / Karl Skoreeki
275 Dialysisin the Treatmentof RenalFailure 1772Kathleen D. Liu / Glenn M. Chertow
276 Transplantationin theTreatmentof RenalFailure 1776Charles B. Carpenter / Edgar L. Milford /
Mohamed H. Sayegh
277 Glomerular Diseases .. . .. . .. . . .. . . .. . .. . . .. . . .. .. 1782Julia B. Lewis / Erie G. Neilson
278 Polycystic Kidney Disease andOther Inherited Tubular Disorders . . . . . . . . . . . . . . . .. 1797
David J. Salant / Parul S. Pate/
279 Tubulointerstitial Diseases of the Kidney . . . . . . .. .. 1806Alan S. L. Yu / Barry M. Brenner
280 Vascular Injury to the Kidney ... .. .. ... ... .... .... 18Il
Kamal F. Badr / Barry M. Brenner
281 Nephrolithiasis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1815
John R. Asplin / PredrieL. Coe/ Murray J. Pavus
282 Urinary Tract Infections,Pyelonephritis, and Prostatitis . . . . . . . . . . . . . . . . . . .. 1820
Walter E. Stamm
283 Urinary Tract Obstruction . . . . . . . . . . . . . . . . . . . . . . . .. 1827
JulianL. Seifter/ BarryM. Brenner
xiv ~ PART13 Disorders01theGastrointestinal System.. DISORDERSOFTHEALlMENTARYTRAO
284 Approach to the Patient withGastrointestinalDisease 1831
WilliamL.Hasler/ Chung Owyang
285 GastrointestinalEndoscopy.. . . . . . . . . . . . . . . . . . . . . .. 1836
Louis Michel Wong-Kee-Song/ Mark Topazian" e25 VideoAtlas01GastrointestinalEndoscopy.. . .. .e195Louis Michel Wong-Kee-Song/ Mark Topazian
286 Diseases01theEsophagus.... ... ... ... .. 1847Raj K. Goyal
287 PepticUlcerDiseaseand RelatedDisorders.. .. ... .. 1855JohnDel Valle
288 Disorders01Absorption 1872HenryJ.Binder
289 InflammatoryBowelDisease 1886SoniaPriedman/ RichardS.Blumberg
290 Irritable BowelSyndrome 1899Chung Owyang
291 DiverticularDiseaseandCommonAnorectalDisorders 1903SusanL. Gearhart
292 Mesenteric VascularInsufficiency 1910Susan L. Gearhart
293 AcuteIntestinalObstruction 1912Susan L. Gearhart/ William Silen
294 AcuteAppendicitisand peritonitis 1914Susan L. Gearhart/ William Si/en.. LlVERAND BILlARY TRAO DISEASE
295 Approach tothepatientwithLiverDisease 1918MarcGhany/ JayH. Hoofnagle
296 Evaluation01LiverFunction 1923Daniel S. Pratt / MarshallM.Kaplan
297 TheHyperbilirubinemias 1927Allan W Wolkoff
298 Acute Viral Hepatitis.. ... ... ... . .. . ... ... ... ... .. 1932JulesL. Dienstag
299 ToxicandDrug-InducedHepatitis ... 1949Jules L. Dienstag
300 Chronic Hepatitis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1955
Jules L. Dienstag
301 AlcoholicLiverDisease 1969Mark E. Mailliard/ MichaelF.Sorrell
302 Cirrhosisand Its Complications.................... 1971BruceR.Bacon
" e26 Atlas01LiverBiopsies .e203JulesL. Dienstag/ Atul K. Bhan
303 Genetic,Metabolic,and InliltrativeDiseases Affecting the Liver. . . . . . . . . . . . . . . . . . . . . .. 1980Bruce R. Bacon
304 Liver Transplantation . . .. . . . .. . . . . . . . . . . . . . . . . . . .. 1983Jules L. Dienstag / Raymond T. Chung
305 Diseases01the Gallbladderand Bile Ducts.... ... .. 1991
Norton J.Greenberger / Gustav Paumgartner
..DISORDERS OF THE PANCREAS
306 Approach to the Patientwith Pancreatic Disease . . . . . . . . . . . . . . . . . . . . . . . . .. 2001
Phillip P. Toskes / Norton J. Greenberger
307 Acute and Chronic Pancreatitis . . . . . . . . . . . . . . . . . . .. 2005Norton J. Greenberger / Phillip P. Toskes
~. PART14 Disorders01 the ImmuneSystem, ConnectiveTissue,and Joints.. THE IMMUNESYSTEMIN HEALTHAND DISEASE
308 Introductionto the Immune System 2019Barton F.Haynes / KellyA. Soderberg / Anthony S.Pauci
309 TheMajor HistocompatibilityComplex 2045Gerald T. Nepom
310 Primary Immune Deliciency Diseases 2053Max D. Cooper / Harry W Schroeder,Jr.
" e27 PrimaryImmunodelicienciesAssociatedwith or Secondary to Other Diseases . . . . . . . . . . . . . . . e207Max D. Cooper / Harry W Schroeder,Jr...DISORDERS OF IMMUNE-MEDIATED INJURY
311 Allergies, Anaphylaxis, andSystemicMastocytosis 2061K. PrankAusten
312 Autoimmunity and AutoimmuneDiseases 2071PeterE. Lipsky / Betty Diamond
313 SystemicLupusErythematosus 2075BevraHannahs Hahn
Rheumatoid Arthritis 2083PeterE.LipskyAcute Rheumatic Fever. . . . . . . . . . .. . . . . . . . . .. . . . .. 2092
JonathanR. Carapetis
SystemicSclerosis(Scleroderma)and RelatedDisorders 2096John Varga
Sjogren'sSyndrome 2107HaralamposM. Moutsopoulos
TheSpondyloarthritides 2109Joel D. Taurog
TheVasculitisSyndromes 2119CarolA. Langford/ Anthony S. Pauci
e28 Atlas 01 Clinicallmaging inthe Vasculitic Syndromes . . . . . . . . . . . . . . . . . . . . . . . . . . e209Carol A. Langford / Anthony S. Pauci
Beh~et's Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 2132
Haralampos M. Moutsopoulos
Relapsing Polychondritis .. ... ... . ... . .. .. 2133Carol A. Langford / Bruce C. Gilliland
Sarcoidosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 2135
Robert P. Baughman / Elyse E. Lower
FamilialMediterraneanFever 2142Daniel L. Kastner
324 Amyloidosis 2145David C. Seldin / Martha Skinner
314
315
316
317
318
319
320
321
322
323
__DISORDERSOFTHEJOINTSANDADJACENTTlSSUES
325 Approachto ArticularandMusculoskeletalDisorders 2149JohnJ.Cush/ PeterE.Lipsky
326 Osteoarthritis 2158DavidT.Fe/son
327 Goutand OtherCrystal-AssociatedArthropathies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2165
H. Ralph Schumacher/ Lan X. Chen
328 InfediousArthritis... ... ... ... ... .. 2169LawrenceC.Madoff
329 Fibromyalgia 2175CarolA. Langford/ BruceC. Gilliland
330 ArthritisAssociatedwith SystemicDiseaseandOtherArthritides.... ... . ... ... .. 2177
CarolA. Langford/ BruceC. Gilliland
331 PeriarticularDisordersof the Extremities 2184CarolA. Langford/ BruceC. Gilliland
~. PART1S Endocrinolog'y;r- and Metabohsm
__ENDOCRINOLOGY
332 PrincipiesofEndocrinology.... .. . .. . 2187J.Larry Jameson
333 DisordersoftheAnteriorPituitaryand Hypothalamus . .. .. .. .. . .. .. . . .. . .. .. .. .. .. .. 2195Shlomo Me/med / J.Larry Jameson
334 Disordersof the Neurohypophysis ................. 2217
GaryL. Robertson
335 Disorders ofthe Thyroid Gland . .. . .. .. .. . . .. . . .. . . 2224
J.Larry Jameson/ Anthony P.Weetman
336 Disordersof the AdrenalCortex 2247Gordon H. Williams / Robert G. Dluhy
337 Pheochromocytoma 2269Hartmut P.H. Neumann
338 DiabetesMellitus 2275Alvin C.Powers
339 Hypoglycemia 2305PhilipE.Cryer
340 Disordersof the TestesandMale Reprodudive System .. . .. . . .. . . .. . .. .. . .. .. . 2310Shalender Bhasin / J. Larry Jameson
341 TheFemaleReprodudiveSystem:Infertility and Contraception., . . . . . . . . . . . . . . . . . . . . 2324JanetE.Hall
342 TheMenopauseTransitionandPostmenopausalHormoneTherapy.. . . . . . . . . . . . . . . 2334JoAnnE.Manson / Shari S.Bassuk
343 Disordersof SexDevelopment 2339John C. Achermann / J. Larry Jameson
344 EndocrineTumorsof theGastrointestinalTradandPancreas.... ... . ... ... .. 2347RobertT.Jensen
345 DisordersAffeding MultipleEndocrineSystems 2358CamiloJimenez / RobertF.Gage/
..DISORDERS OF BONE AND MINERAL METABOLlSM
346 Doneand Mineral Metabolismin Health and Disease . . . . . . . . . . . . . . . . . . . . . . . . . . .. 2365
F.RichardBringhurst / Marie B. Demay /Stephen M. Krane/ Henry M. Kronenberg
347 Diseasesof the parathyroidGlandandOtherHyper-and HypocalcemicDisorders 2377John T. Potts, Jr.
348 Osteoporosis 2397
Robert Lindsay / Fe/icia Cosman
349 pagetDiseaseandOtherDysplasiasofDone.. . . . .. 2408
Murray J. Favus / Tamara J. Vokes
xv
__DISORDERSOFINTERMEDIARYMETABOLlSM
350 Disordersof LipoproteinMetabolism .. .... ... 2416DanielJ. Rader / He/enH. Hobbs
351 Hemochromatosis 2429Lawrie W Powell
352 ThePorphyrias 2434RobertJ. Desnick/ Kenneth H. Astrin
DisordersofpurineandPyrimidineMetabolism.. .. 2444Robert L. Wortmann
WilsonDisease 2449
George J. Brewer
LysosomalStorageDisease... ... ... 2452RobertJ. Hopkin / GregoryA. Grabowski
Glycogen Storage Diseases and OtherInheritedDisordersof Carbohydrate Metabolism . .. 2457Yuan- Tsong Chen
Heritable Disorders of Connedive Tissue. . . . . . . . . .. 2461
Darwin J. Prockop / Malwina Czarny-Ratajczak
Inherited Disorders of Amino AcidMetabolismin Adults 2470
Nicola Longo
Inherited Defeds of Membrane Transport 2474
Nicola Longo
e29 Atlas of Clinical Manifestationsof Metabolic Diseases .e215
J. Larry Jameson
353
354
355
356
357
358
359
-" PART 16 NeurologicDisorders_DIAGNOSIS OF NEUROLOGIC DISORDERS
360 Mechanismsof NeurologicDiseases .. ... ... . .. 2477Stephen L. Hauser / M. Flint Beal
361 Approach to the patient with Neurologic Disease . .. 2484Danie/ H. Lowenstein / Joseph B. Martin /
Stephen L. Hauser
362 Neuroimaging in Neurologic Disorders 2489William P. Dillon
fj e30 Atlas of Neuroimaging e225Andre Furtado / William P. Dillon
fj e31 ElectrodiagnosticStudiesof NervousSystemDisorders: EEG,Evoked Potentials, and EMG. . . . . . . . . e261Michae/J. Aminoff
fj e32 Technique of Lumbar Pundure . . . . . . . . . . . . . . . .e267Elizabeth Robbins / Stephen L. Hauser
xvi .. OISEASESOFTHECENTRALNERVOUSSYSTEM
363 Seizures and Epilepsy 2498DanielH. Lowenstein
364 CerebrovascularDiseases.. .... ..... ... .. ... . 2513WadeS.Smith/ JoeyD. English/ S.ClaiborneJohnston
365 Dementia 2536ThomasD. Bird / BruceL.Mil/er
366 Parkinson'SDiseaseand OtherExtrapyramidalMovementDisorders 2549Mahlon R.DeLong/ JorgeL.Juncos
367 HyperkineticMovementDisorders.. . . . . . . . . . . . . . .. 2560C. Warren Olanow
368 Ataxic Disorders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 2565
RogerN. Rosenberg
369 Amyotrophiclateral SderosisandOtherMotorNeuronDiseases 2572Robert H.Brown,Jr.
370 DisordersoftheAutonomicNervousSystem.. . . . . .. 2576Phil/ip A. Low / John W Engstrom
371 Trigeminal Neuralgia, Bell's palsy, andOther Cranial Nerve Disorders . . . . . . . . . . . . . . . . . . . .. 2583
M. Flint Beal / Stephen L. Hauser
372 Diseases of the SpinalCord.. . . . . . . . . . . . . . . . . . . . . .. 2588
Stephen L. Hauser / Allan H. Ropper
373 Concussion andOtherHeadInjuries.. . . . . . . . . . . . . . . 2596Allan H. Ropper
374 Primaryand MetastaticTumorsof the NervousSystem 2601Stephen M. Sagar/ Mark A. Israel
375 Multiple Sderosisand OtherDemyelinatingDiseases 2611StephenL. Hauser / DouglasS. Goodin
376 Meningitis,Encephalitis,BrainAbscess,and Empyema 2621Karen L. Roos / Kenneth L. Tyler
377 ChronicandRecurrentMeningitis.... ... . .. . . 2641WalterJ.Koroshetz/ Morton N. Swartz
378 prion Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2646
Stanley B. Prusiner / Bruce L. Mil/er..NERVEANOMUSCLEOISOROERS
379 PeripheralNeuropathy.. ... ... ... .... ... .. 2651Vinay Chaudhry
380 Guillain-BarréSyndromeand OtherImmune-MediatedNeuropathies.. . . . . . . . . . . . . . . .. 2667Stephen L. Hauser / Arthur K. Asbury
381 Myasthenia Gravis and Other Diseasesof the Neuromuscular Junction . . . . . . . . . . . . . . . . . . .. 2672
Daniel B. Drachman
382 Muscular Dystrophies andOther Musde Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . .. 2678
Robert H. Brown, Jr. / Anthony A. Amato /Jerry R. Mendell
Polymyositis, Dermatomyositis,and Indusion Body Myositis 2696Marinos C. Dalakas
e33 Speciallssues in InpatientNeurologic Consultation .e271S. Andrew Josephson / Martin A. Samuels
383
_ CHRONICFATIGUESYNOROME
384 Chronic Fatigue Syndrome. . . . . . . . . . . . . . . . . . . . . . .. 2703Stephen E. Straus_ PSYCHIATRICOISOROERS
385 Biology of Psychiatric Disorders. . . . . . . . . . . . . . . . . .. 2705Steven E. Hyman / EricKandel
386 Mental Disorders 2710Victor 1.Reus
__ ALCOHOLlSMANOORUGOEPENOENCY
387 Alcoholand Alcoholism 2724Marc A. Schuckit
388 OpioidDrugAbuseand Dependence 2729Marc A. Schuckit
389 Cocaineand OtherCommonlyAbusedDrugs. . . . ... 2733Jack H. Mendelson / Nancy K. Mello
390 Nicotine Addiction . . .. . .. .. .. . .. . .. . . .. .. . . . . . oo. 2736David M. Burns
-~ PART17 Poisoning, DrugOverdose,and Envenomation
e34 Heavy Metal Poisoning . . . . . . . . . . . . . . . . . . . . . . . e277Howard Hu
e35 Poisoning and Drug Overdosage e281Christopher H. Linden / Michael J. Burns /
Mark B. Mycyk
Disorders Caused by Reptile Bitesand MarineAnimal Exposures 2741Paul S. Auerbach / Robert L. Norris
Ectoparasite Infestations andArthropodBitesand Stings 2748Richard J. Pollack/ JamesH. Maguire
391
392
-~ PART18 e-ChaptersfromInternationalAdvisoryEditors
e36 pulmonaryBiomarkersinCOPO .. . . . . . . . .. e297Peter J.Barnes
e37 Chagas'Disease:Advancesin Diagnosisand Management e303Andrei C. Sposito/ JoseA. F.Ramires
e38 ThePolypill e307K. Srinath Reddy / Nitish Naik / Ambuj Roye39 MitochondrialDNAandHeritable Traitsand Diseases.. . . .. . .. .. . .. . . . .. . .. e311Karl Skorecki / Hanna Mandel
APPENOIXlaboratory Values of Clinicallmportance . . . . . . . . . . . . . . . . . .A-lAlexander Kratz/ MichaelA. Pesce/ DanielJ. Fink
INOEX 1-1