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De Nederlandse Hersenbank voor Psychiatrie: Oog voor details

Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

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Page 1: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

De Nederlandse Hersenbank voor Psychiatrie:

Oog voor details

Page 2: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

ASS: tekortkoming of talent

Page 3: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Wat is er dan anders?

Page 4: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Postmortem: de missing link?

MRI DNA

Dier NHB-Psy

Page 5: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Donor Onderzoeker

De Nederlandse Hersenbank

Page 6: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal
Page 7: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

N = 4039(26 juli 2016)

CO = controleFTLD/Tau = frontotemporale dementieMS = multiple sclerosePD = ziekte van ParkinsonPSP = progressieve supranucleaire paralysePsych = psychiatrische aandoeningAD = ziekte van AlzheimerRest = overige ziektebeeldenDem = overige dementieën

Registraties

Page 8: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

1 uitsnijdprotocol

1. Snelle'obduc- e'volgens'protocol

2. Samenva7 ng'medische'gegevens

3. Gespecialiseerde'neuropathologische'diagnose

2. Obductie, diagnostiek en opslag

Page 9: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Binnen ziekten meer homogenere subgroepen onderzoekenTussen ziekten overlappende symptomen onderzoeken

Page 10: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Via iPSCs(stamcellen)

Microglia Astrocyten Neuronen

NHB-Psy: cellen waar we mee werken

Page 11: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal
Page 12: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Het immuunsysteem in ASS

Page 13: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Microglia fenotypes

Page 14: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal
Page 15: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal
Page 16: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

NHB-Psy maakt meer mogelijk

Page 17: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Stress gerelateerde genexpressie:verschil depressie - suïcide

Page 18: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Suïcidaliteit:Meer suïcidale gedachten bij personen met stoornis van Asperger

Lancet Psychiatry, 2014

Page 19: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Doel NHB-Psy: boost onderzoek door meer breinen

Page 20: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal

Nieuwe inzichten Beter begrip van de ziekte

Verbeteren bestaande therapieënOntwikkelen van nieuwe therapieën

Page 21: Oog voor details - Autisme · significant increase was found for CRH mRNA expression in MDD patients who had committed suicide compared to the MDD patients who died of non-suicidal