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8/8/2019 Pentose Phosphate Shunt Presentation
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` Used to generate NADPH and specialized productsneeded by the cell.
` Also known as:
1. Hexose monophosphate shunt.
2. Phosphogluconate pathway.
`
Operating in two phases:1. Oxidative phase.
2. Non-oxidative phase.
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1. Used for production of NADPH (the universal reductant
in anabolic pathways) from NADP.
2. Used for the production of ribose for nucleotide andnucleic acid synthesis.
3. Acts as a connection route between different pathways.
- allows the entry of some carbohydrates into the
glycolytic pathway.
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Glucose6 phosphateglucose6
phosphate dehyrogenase
6phosphogluconolactonegluconolactone hydrolase
6phosphoglocunate6
phosphoglocunate dehydrogenase
Ribulose5phosphatephosphopentose isomerase
Ribose5phosphate
NA
DP+
NADPH+H+
NADP+
NADPH
dehydrogenation
dehydrogenation
isomerisation
CO2 +
H2OH+
hydrolysis
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`
Oxidative phase Reactions produce NADPH Irreversible reaction3Glucose-6-phosphate + 6NADP+ 3 ribose-5P + 3CO2 +
6NADPH + 6H+
` Non-Oxidative phase
Produces 2-Fructose-6-Phosphate and Glyceraldehyde -3-Phosphate. Reversible reactions feed to glycolysis
2 Xylulose-5P + ribose-5P 2 Fructose-6P + Glyceraldehyde-3P
The sum of these two phases:
3Glucose-6-phosphate + 6NADP+ 2 Fructose-6P +Glyceraldehyde-3P + 3CO2 + 6NADPH + 6H+
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