Upload
innoventurecommunity
View
218
Download
0
Embed Size (px)
Citation preview
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
1/18
Presenters: Justin Nice and Graham Temples
Lab members: Benjamin Green, So-jung Gwak, PhD
Advisor: Jeoung Soo Lee, Ph.D.
Clinical Mentor: Michael Lynn, MD
Drug Design, Development and Delivery(4D Lab)
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
2/18
Diseased sites
Why do we need
Targeted Drug Delivery System?Magic Bullet or Guided Missiles
Conventional Targeted
Maximize the therapeutic effect Minimize systemic side effect
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
3/18
Drug + Gene therapy
Combinatorial Therapy?
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
4/18
Tissue-specific Delivery System
10-200 nm
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
5/18
Innovative features of nanoparticle
delivery system1. Change targeting domain depending on cell
type
2. Encapsulate currently approved drugs to treatany diseases or regenerate tissue
3. Incorporate any genes to treat any diseases or
regenerate tissue
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
6/18
Neuron-specific Polymeric
nanotherapeutics for neural regeneration
Traumatic brain injury
* 1.5-2 million people in the US each year
* 2.5-6.5 million people are living with the physical,
psychological and economic consequences
Spinal Cord Injury*200,000 people in the US are currently living with
spinal cord injury
*12,000-20,000 new cases each year in US
* chronic pain, spasticity, respiratory impairment,
loss of bowel or bladder control, and sexual dysfunction
No effective drug therapy
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
7/18
Neonatal
Neuron
Barriers to CNS Regeneration
Adult
NeuronChanges external environment
Changes in biochemistry
Pliable
Can regenerate
Fixed
Cant regenerate
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
8/18
Neuron-specific Nanoparticles
Targeting Using antibody specific to neurons
Encapsulation of Drug Increase regrowth and decrease inhibitory
molecules Gene Delivery In order to knockdown the expression of growth
inhibitory molecules
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
9/18
Neuron-specific Polymeric
nanotherapeutics for neural regeneration
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
10/18
Cancer and its current treatments
Cancer is the leading cause of
death
Greater than
HIV/AIDS, tuberculosisand malaria combined
Current treatments include
Radiotherapy
Surgery Chemotherapy
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
11/18
Targeted Multi-functional Nanotherapeutics for
Combinatorial Therapy of Drug Resistant Cancer
Cancer is the result of
cumulative genetic
defects
It can start anywhere
Takes on a variety offorms
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
12/18
Targeted Multi-functional Nanotherapeutics for
Combinatorial Therapy of Drug Resistant Cancer
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
13/18
Targeted Multi-functional Nanotherapeutics for
Combinatorial Therapy of Drug Resistant Cancer
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
14/18
Cancer Cell
Normally
Cell Dies
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
15/18
Drug Resistant Cancer Cell
However
Pump Numbers IncreaseCell Lives
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
16/18
Drug Resistant
Cell Dies
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
17/18
How to meet the challenges?
Drug Delivered
Safely?
Drug Delivered to
Target?
Is resistanceaddressed?
Targeting moeity
sequesters drug at
desired area
Toxic drug encapsulated
Gene therapy reducespotential drug resistance
in cancer cells
7/29/2019 Presentation File 5237ba27 Abd8 40ea Bcdb 0eb4ac102202
18/18
Thank You!
Drug Design, Development and Delivery(4D Lab)