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8017
8017
8017
8017
8017
8017
8017
8017
8017
8017
8017
8017
8017
8016
8016
80168016
8016
80498049
8031
8031
8031
8031
8031
8031
8031
8031
8031
8031
8031
8031
8031
8010
8010
8010
8006
8006
8006
8006
8006
8006
8006
8006
8006
8045
8045
8016
8016
8016
8016
8016
8044
8044
8044
8044
8044
8044
8018
8018
8018
8049
8049
8049
8049
8049
8023
8040
8040
8040
8040
8040
8040
8040
8040
8040
8040
8049
8049
8049
SUBJECT INDEX
S-l
1958
ABSORPTION
aniline
dissociation constant
drug concentration
foreign compounds
lipoid barrier
membrane solubility
organic acids
organic bases
pH
pKa values
quaternary aniunonium
compounds
salicylic acid
small intestine
ACETALDEHYDE
alcohol administration
blood level
charcoal pretreatment
charcoal treatment
cyanamide pretreatmentdisul firam pretreatment
ACETAZOLAMIDE
blood acid-base balance
carbonic anhydrase
8049
diuretic action
electrolyte excretion
electrolyte reabsorption
meral luri de
metabolic acidosis
natriuretic action
sequence administration
urinary excretion patterns
ACETYLCHOLINESTERASE
ambenonium analogs
DFP-inactivation
diacetylmonoxime(DAM)
histochemical examination
intercostal muscle
monoi sonitrosoacetone(MINA)
quantitative activity
determinations
reactivation in vivo
stellate ganglion
superior cervical ganglion
tissue homogenates
ACID-BASE
acetazolamide
chloride excretion
mercurial diuresis
ABS -ALK
metabolic acidosis 8049
plasma chloride
concentration
renal intracellular acidosis
ACRYLANIDE
acute poisoning
ataxia
behavioral disturbances
blood pressure
brain stem effects
central excitation
chronic poisoning syndrome
EEC patterns
elect rospinograms (ESP)
mass sympathetic discharge
neurologic deficit
8016 tonic-clonic convulsions
tremors
ACTh
adrenal ascorbic acid
depletion
chlorpromazine pretreatment
reserpine pretreatment
8049 ADRENALECTOMY
8018 anesthetized rabbit
blood pressure
histamine response
ADRENERGIC BLOCKADE
adrenalectomy
blood pressure
DHE
epinephrine response
histamine response
phentolamine
ADRENERGIC BLOCKING AGENTSdibenamine
rauwol scine
ALCOHOL
blood level
charcoal pretreatment
charcoal treatment
human subjects
oral administration
2-ALKOXYBENZOATES
irri tancy
local anesthetic activity
systemic toxicity
2 -ALKOXYTHIOLBENZOATES
irri tancy
local anesthetic activity
systemic toxicity
8023
8038
8022
8012
8022
8022
8022
8022
8038
8034
8034
8048
8048
8014
8014
8010
8010
8010
8010
8022
8022
8022
8032
8022
8032
8038
8038
8038
8038
8038
8038
8030
8030
8030
8030
8030
8030
8030
8030
8006
8006
8006
8044
8044
8044
8044
8044
8044
8044
8040
8040
8040
8040
AMB -AUT
SUBJECT INDEX
VOL. 123
S-2
AMBENONIUM ANALOGS
anticholinesterase activity
skeletal muscle
structure action correlations
toxicity
AMINE OXIDASE
imidazole-acylcholine esters
2 -AMINO-5 -CHLOROBENZOXAZOLE
(FLEXIN)
spinal segmental reflexes
AMINOPHTYLLINE
antipruritic activity
human subjects
AMPHETAMINE
blood pressure
methyiphenidate
nictitating membrane
d-AMPHETAMINE
human subjects
learning rate
reaction time
ANALGESICS
demethylating enzyme
receptors
3 -hydroxy -N-al lylmorphinan
inhibition
3-hydroxyl group
etheri ficat ion
liver microsome system
morphinan - type
morphinan-type isomers
morphine analogs
narcotic action receptors
N-demethylation
0-demethylati on
ANESTHESIA, GENERAL
anesthetized rabbit
blood pressure
histamine response
ANESTHETICS ,LOCAL
activitycorrelation studies
intradermal injection
intraspinal injection
i rn tancy
statistical evaluation
systemic toxicity
threshold anesthetic
concentration
threshold irritant
concentration
ANTICHOLINESTERASES
8023 ambenonium analogs
8023 atropine-like protective
8023 agents
8023 central respiratory control
halopyruvic acids
8019 morphine
neuromuscular transmission
phospholine
8029 phospholine analog (2l7-AO)
TEPP toxicity
8036 ANTICONVULSANTS
8036 CNS stimulants
reserpine influence
8007 ANTIEMETIC AGENTS
8007 chlorpromazine
8007 perphenazine
ANTIRHEUMATIC AGENTS
8035 phenylbutazone metabolites
8035 ARTHRITIS ,ACUTE GOUTY
8035 phenylbutazone metabolites
ASCORBIC ACIDacute stress
8030 adrenal gland depletion
chl orproinazine
8030 reserpine
ATROPINE
antagonistic action
central nervous system
cholinesterase activity
conditioned avoidance
responses
phospholine analog (217-AO)
reserpine
ATROPINE METHYLNITRATE
(EUMYDRINE)
atropine substitutes
mytolon
protective action
TEPP toxicity
ATROPINE SUBSTITUTES
anti-TEPP activity
CNS activity
peripheral cholinolytic
potency 8038
AUTONOMIC GANGLIA
acetylcholinest erase
activity
8044 DFP pretreatment
diacetylmonoxime(DAM)
8044 monoi sonitrosoacetone(MINA)
AUT-BLO
8019
8024
8007
8006
8046
8047
8046
8004
8046
8046
8004
8022
8007
8004
8006
8047
8045
8024
8004
8006
8024
8019
8045
8004
8045
8039
8007
8046
8039
8046
8039
8022
8022
8022
8045
8007
8047
8034
8015
8015
8034
8015
8015
8015
8015
8015
8038
8038
8038
8038
8023
8023
8023
8023
8023
8023
8023
8023
8045
8045
8045
8046
8045
8046
correlations
SUBJECT INDEX
S-3
1958
AUTONONIC NERVOUS SYSTEM,
CENTRAL
acrylamide poisoning
atropine
conditioned avoidance
responses
epinephrine
e serine
I evarterenol
mass sympathetic discharge
methamphet amine
reserpine
BARBITAL
anticonvulsant activity
blood-brain barrier
lipid solubility
reserpine influence
BARBITURATES
brain concentration
brain penetration
hypnotic effects
lipid solubility
plasma concentration
BENZOQUINONIUM (MYTOLON)
atropine substitutes
eumydrine
protective action
TEPP toxicity
N,N’ -BIS(DIETHYLAMINOETHYL) -
OXAMIDE -BIS -BENZALDEHYDE
anticholinesterase activity
motor facilitation
muscle relaxation
neostiginine potentiation
quaternary salts
structure action
TEPP antagonism
toxicity
BLOOD FLOW
atropine
epinephrine
femoral vascular bed
8046
narcot me
rauwol scine
tachyphylaxi s
BLOOD PRESSURE
acetylcholine
8031 amphetamine
8032 amphetamine hypertension
anesthetized rabbit
8032 antihistainines
8032 8047
8032 arterial pressure
8032 atropinization
8031 8047
8032 BITU
8032 carotid body denervation
carotid sinus denervation
chlori sondamine
8039
cholinesterase activity
C-O pressor response
8045 8047
DMPP
8019
epinephrine
8019
epinephrine pressor response
epinephrine reversal
hydroxy-l -azepine-
propionamidoxime
hexamethoni um
histamine
8019
hypertensive dogs
imidazole-acylcholine esters
isoproterenol depressor
response
1 evarterenol
8024
levarterenol pressor
response
8047
malignant renal hypertension
methylphenidate
narcotine hypotension
neurogenic hypertension
papaveri ne
pentobarbital anesthesia
phentolamine pretreatment
phospholine
phospholine analog (2l7-A0)
rauwol scine
renal hypertension
right atrial pressure
VOL. 123
8047
8019
8046
8047
8039
8046
8015
8015
8015
8034
8034
8034
8034
80088008
8008
8034
8008
8043
8043
8043
8043
8043
8037
8037
8018
8024
8004
80078046
8046
8045
8047
8031
8031
8034
8034
8038
8032
8008
8033
80228034
8032
8008
8033
8033
8008
8033
8032
8046
8022
8022
8033
8033
8032
8022
80088033
8033
8038
8034
8016
8016
8016
8016
8016
80168016
8028
8028
8028
8007
8004
8047
8004
8046
8046
SUBJECT INDEX
S-4
BLO-CHA
ryanodine hypotension
serotonin
tachyphylaxi s
TEA
unanesthetized mammals
vagotomy
8047
BRAIN
lipid solubility
oxybarbiturate penetration
thiobarbiturate penetration
BRAIN STEM
acrylamide action
chronic poisoning
CAFFEINE
anti convulsant s
clonic seizures
CNS antiextensor excitants
reserpine
rigidity
salamander
spinal cord transection
tonic extensor seizures
tonic seizures
CALCIUMCa45 distribution
erythrocyte transport
human erythrocytes
ouabain
potassium transport
CARBON TETRACHLORIDEhepatotoxici ty
lethal potency
CARBONIC ANHYDRASE
acetazolamide inhibition
8049
chiorothiazide inhibition
meralluride diuresis
CARDIAC GLYCOSIDES
environmental temperature
myocardial response
ouabain
CARDIOVASCULAR SYSTEM
antihypertensive activity
bis-isothiourea (BITU)
circulatory failure
DMPP
ECG
hemodynamic responses
hexahydro-l -azepine-
propionamidoxime (Su-4029)
levarterenol
methylphenidate
narcotine
papaverine
rauwol scine
ryanodine
CENTRAL NERVOUS SYSTEM
acrylamide poisoning
action localization
anticonvul sant s
8031 antiextensor excitants
8031 atropine-like antidotes
autonomic changes
behavior
8032 8033biological variation
cholinesterase activitycomparative study
conditioned avoidance
responses
convulsant drugs
8034
crossover techniques
depressant drug sensitivity
electrical activity
locomotor activity
methamphetamine reversal
narcotine convulsions
phospholine
phospholine analog (2l7-AO)
post-treatment activity
counts
pretreatment activity counts
reserpine
8034
respiratory control
8018 salamander
8049 statistical evaluations
stimulant drug sensitivity
TEPP toxicity
tonic extensor seizures
CHARCOAL ,ANIMAL
adsorbent agents
alcohol administration
alcohol metabolism
alcohol sensitivity
alcoholic patients
blood acetaldehyde levels
blood alcohol levels
8016
8016
8016
8016
8016
8016
8013
8049
8049
8049
8049
8049
8039
8039
80398039
8039
8039
8039
8039
8039
8039
8018
8018
8018
CHA-COR
8019
8019
8019
8019
8019
8019
8021
8012
8021
8020
8019
8012
8021
8021
8020
8021
8021
8038
8038
8038
8038
8034
8034
8032
8032
8032
8032
8008
8008
8008
8008
8008
8008
8008
8048
8048
8048
8048
8046
8046
8046
8010
8010
8048
8010
8033
8009
8048
8010
8033
8033
8009
SUBJECT INDEX
S-5
1958
chemical analysis
di sul firam-like action
extraction studies
oral administration
toxicity
vegetable charcoals
CHEMOTHERAPY ,VIRUSpurines
CHLORIDE EXCRETION
ace t azo lami de
mercurial diuresis
metabolic acidosis
plasma chloride
concentration
renal intracellular acidosis
CHLORISONDAMINE
cardiac output
cardiac volumediastolic blood pressure
ganglionic blocking action
heart rate
hexame thoniummean blood pressure
pentobarbital anesthesia
peripheral resistance
unanesthetized dogs
CHLORMERODRIN
diuretic action
electrolyte excretionelectrolyte reabsorption
CHLOROFORM
hepatotoxici ty
lethal potency
CHLOROTHIAZIDE
carbonic anhydrase
diuretic action
electrolyte excretion
electrolyte reabsorption
CHLORPROMAZINE
acute stress
adrenal ascorbic acid
antiemetic activity
exogenous ACTH
locomotor responses
MET
perphenazine
pituitary adreno-
corticotrophic activity
post-treatment counts
pretreatment counts
spontaneous motor activity
CHOLINE ESTERS
brain homogenates
comparative actionsdihydromurexine
hydrolysis
imidazoleacetylcholine
murexine
CHOLINESTERASES
esterolytic activity
halopyruvic acids
human blood serum
imidazoleacetylcholine
imidazole-acycholine esters
inhibition
metal ion influence
n-fatty acid esters
pyridylacetylcholine
spectrophotometric method
substrate variationCHOLINOLYTIC AGENTS
anti-TEPP activity
mydriatic activity
peripheral potency
substituted tertiary amines
COCAINE
antiextensor seizure
activity
CNS stimulants
CONDITIONED REFLEXES
approach responses
avoidance responses8037 methamphetamine reversal
8037 reserpine suppression
CONVULSANTS8018 behavior
8018 CNS
8018 electrical activity
8018 muscular systemneurological tests
salamandersensory-motor side effects
COPPER SULFATE
chl orpromazine
emetic action
intragastric threshold
perphenazine
CORONARY BLOOD FLOWcoronary resistance
narcot me
papaverine
VOL. 123
8016
8016
8016
8016
8030
8030
8030
8030
8030
8030
8030
8030
8016
8016
8016
8016
8016
8018
8018
8018
8018
8018
8047
8031
8018
8014
8018
8018
8014
8017
8017
8017
8017
8009
8009
8048
8048
8048
8048
8048
8021
8021
8021
8006
8045
8005
8047
8032
8027
8027
8027
8004
8004
8007
8007
8034
8034
8046
SUBJECT INDEX
S-6
CYA-EPI
CYANANIDE
alcohol administration
alcohol sensitivity
blood acetaldehyde levels
oral administration
DEMETHYLATION
dealkylation
liver microsome system
3 -methyicholanthrene
3-methyl-NAB
morphinan-type analgesics
morphine analogs
pH optima
SKF 525-A
DESOXYEPHEDRINE
antiextensor seizure
activity
CNS stimulants
DIACETYLMONOXINE
DFP-inactivated
acetylcholinesterasereactivating action in vivo
10 -(2 -DINETHYLANINOPROPYL) -9-
ACRIDONE (ACRIDONE)
anticonvul sant s
clonic seizures
CNS antiextensor excitants
reserpine
tonic extensor seizures
1,1 -DINETHYL-4-PHENYLPIPER-
AZINIIJM (DMPP)
arterial pressure
BITU potentiation
methylpheni date
pressor response
DIPHENHYDRANINE
antiextensor seizure
activity
CNS stimulants
narcotic vasodepression
DIPHENYLHYDANTOIN
anticonvulsant activity
reserpine influence
1, 4-DIPYRROLIDINO-2 -BUTYNE
(TREMORINE)
antiextensor seizure
activity
CNS stimulants
DISULFIRAM
alcohol administration
alcohol sensitivity
alcoholic patients
blood acetaldehyde levels
blood alcohol levels
oral administration
DIURETICS
acetazolamide
action mechanism
chiormerodrin
chiorothiazide
glomerular filtration rate
ELECTROCARDIOGRAMryanodine
ELECTROENCEPHALOGRAM
chronic acrylamide poisoning
8034 ELECTROLYTES
8034 diuretics
phenylbutazone metabolites
renal excretion
8040 renal reabsorption
8040 sodium-retaining effect
ELECTROLYTES ,ORGANIC
intestinal absorption
8034 lipid-solubility
8034 pKa values
8034 unionized form
8034 ELECTROSHOCK
8034 MET
phenothiazine s
EMESIS,DRUG INDUCED
apomorphine -induced
chemoceptive trigger zone
chlorpromazine treatment
emetic agents
perphenazine treatment
ENZYMES
human blood serum
hydrolysis
rn-hydroxybenzoic acid esters
EPINEPHRINE
8034 anesthetized rabbit
8034 blood pressure
cardiac effects
cardiac stimulation
conditioned avoidance
8034 responses
8034 heart content
heart-lung preparation
8016 heart rate
8021
8021
8021
8021
8021
8021
8021
EPI-HEA
8005
8004
8047
8004
8039
8039
8004
8005
8039
8047
8004
8047
8005
8005
8047
8047
8027
8027
8024
8027
8027
8027
8027
8047
8047
8047
8026
8039
8039
8026
8026
8027
8046
8039
80458027
8026
8026
8005
8028
8028
80398039
8006
8006
80068006
8039
8005
8005
8005
SUBJECT INDEX
S-7
1958
hi stamine antagonism
nictitating membrane
peripheral vascular
resi stance
plasma content
pressor effect
rat lung content
rauwol scine
re serpine
reserpine pretreatment
ryanodine cardiac depression
ERYTHROCYTES
buffer suspension
calcium transport
cold stored blood
fresh blood
membrane lipid factor
plasma suspension
potassium transport
ESERINE
conditioned avoidance
responses
reserpine
ESTERASESesterolytic activity
human blood serum
rn-hydroxybenzoic acid esters
metal ion influence
n-acyl carbon atoms
physosti ginine
serum cholinesterase
GANGLIONIC BLOCKADE
adrenal ectomy
blood pressure8039
chlori sondaminecompensatory mechanisms
epinephrine response
hexamethoni umhistamine response
pendiomide
pentobarbital anesthesia
HEART
absolute refractory period
action potential
arrhythmia
8047
8006 A-V conduction time
8045 BITU
cardiac arrest
8045 cardiac output
8027 8039 8047
8006 cardiac volume
8027 chlori sondamine
8045 heart-lung prepartion
8032 irritability
8027 pentobarbital
8047 rate
right atrial pressure
8043 ryanodine depression
8043 stimulation threshold
8043 vasopressor agents8043 HEART ARRHYTHMIA
8043 ryanodine
8043 ventricular fibrillation
8043 HEART ,ISOLATED
cardiac rate
heart-lung preparation
8032 hexahydro-l -azepine-
8032 propionamidoxime
levarterenol release
pentobarbital failure
re serpine
verat ramine
HEART MUSCLE
di goxin
ouabain
ryanodine depression
HEART RATE
A-V rhythmblood pressure
8006 chlori sondamine
800& 1-epinephrine
heart-lung preparation
80275 -hydroxytryptamine
narcotine
pentobarbital anesthesia
rauwol scine
reserpine pretreatment
reserpine response
8027
S-A rhythmHEART RHYTHM
vasopressor agents
HEART VENTRICLE
contractile force
frequency
VOL. 123
8034
8034
8034
8037
8037
8037
8037
8024
8024
8024
8024
8024
8024
8024
8039
8039
8028
8028
8028
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
8024
80248024
8024
8024
8024
8024
8024
8006
8006
8006
8006
8006
8006
8046
8006
8019
8019
8020
8019
8019
8019
8019
8019
8019
8019
8019
8019
8019
8019
8019
8019
8019
8019
8019
80198019
8048
8048
8048
REA-IMISUBJECT INDEX
S-8
isolated strips
ouabain
temperatureHEXAHYDRO-l -AZEPINEPROPIONANID-
OXIME (SU-4029)
amphetamine
“annoying” stimulation
antihypertensive effects
blood pressure
central nervous activity
chemical structure
speci ficity
chlori sondamine
C-O pressor response
cumulative effect
DNPP
ECG
ephedrine
epinephrine
ganglionic blocking agents
high cord transection
hypertensive dogs
levarterenol
morphine
nictitating membrane
oral activityphentolamine
reserpine
serotonin
side effects
smooth muscle
toxicity
HISTAMINE
adrenal ectomy
adrenergic blockade
anesthetized rabbit
epinephrine antagoni sm
ganglionic blockade
general anesthesia
narcotine vasodepression
pressor effect
HISTAMINE LIBERATION
compound 48/80
narcotine
HYDERGINE
chl orpromazine
emetic action
perphenazine
1 -HYDRAZINOPHTHALAZINE
anticonvul sant s
clonic seizures
CNS antiextensor excitants
reserpine
tonic extensor seizures
HYDROCARBONS ,HALOGENATEDdose-responses
lethal potency
liver damage
pentobarbital sleeping time
HYPERTENSION
amphetamine-induced
ephedrine-inducedhexahydro-1 -azepinepropion-
amidoxime treatment
naphazol me
neurogeni c
renal
renin
HYPERTENSION ,EXPERIMENTAL
chl on sondamine
ganglionic blockade
IBOGAINE
antiextensor seizure activity 8034
CNS stimulants 8034
IMIDAZOLEACETYLCHOLINE
comparative actionsimidazole-acylcholine esters
neuromuscular function
IMIDAZOLEACRYLCHOLINE
pharmacologic actionsIMIDAZOLE -ACYLCHOLINE ESTERS
acute toxicity
amine oxidaseatropine
autonomic gangliablood pressurecholinesterases
edrophoniumeserine
hexamethoni um
histamine
8046 hydrolysis
8046 neuromuscular function
nictitating membraneperipheral cholinergic
neuroe ffectorsrespiration
smooth muscle8034 d-tubocurarine
8034
8048
8048
8048
hydroxymeprobamate
learning rate
metaboli tes
motor coordination
plasma levels
8035
8035
8035
8035
8035
8004
8004
8005
8032
8027
8027
8027
8007
8027
8007
8027
8032
8027
8030
8030
8030
8030
8030
8030
8037
8037
8037
8037
1141-MET
8005
8041
8041
8041
8035
8041
8035
8041
8035
8041
8035
8041
8049
80498049
8049
8049
8049
8049
8049
8049
8049
8049
8049
8032
8033
80338033
8032
8005
8034
8034
8034
8034
80348009
8009
8034
8007
1958SUBJECT INDEX
S -9
IMIDAZOLEPROPIONYLCHOLINE
pharmacologic actions
LANATOS IDE C
chl orpromazine
emetic action
perphenazine
LEARNING RATE
d-amphetamine
human subjectsmeprobamate
phenobarbi tal
reaction time
LEVARTERENOL
arterial pressure
BITU potentiationcardiac effects
conditioned avoidance
responses
heart content
heart-lung preparation
heart rate
methylphenidate
plasma content
pressor response
rat lung content
reserpine
reserpine pretreatment
LIVER
methylated aminoazo dyes
microsome system
narcotic compounds
N-demethylation
0-demethylation
species differences
LIVER DAMAGE
BSP retention
halogenated hydrocarbons
pathological changespentobarbital sleeping time
LYSERGIC ACID DIETHYLAMIDE
antiextensor seizure
activity
CNS stimulants
MEPAZINE
MET
spontaneous motor activity
NEPHENESINanticonvulsant activity
reserpine influence
MEPHENTERNINE
8019 cardiac effects
)IEPROBANATE
C14-carbamate labeleddistribution
glucuronide
human subjects
8041
reaction time
urinary excretion products
ZIERALLURIDE
acetazolaniide pretreatment
blood acid-base balance
chloruretic action
metabolic acidosis
natriuretic action
plasma chloride
concentration
sequence administration
urinary excretion patterns
MERCURIAL DIURETICS
acetazolamide
blood acid-base balance
meral luride
urinary excretion patterns
METHAMPHETANINE
conditioned avoidance
responses
locomotor responses
post-treatment countspretreatment counts
reserpine
NETHOXANINE
cardiac effects
4-METHYL-4-ETHYL-GLUTARINIDE
(NEGIMIDE)anticonvulsants
8034 clonic seizures
8034 CNS antiextensor excitants
reserpine
tonic extensor seizures
METHYLPHENIDATE
amphetamine 8007
antiextensor seizure
8034 activity
8034 baroreceptor function
VOL. 123
8007
8007
8007
8034
8007
8007
8007
8007
8007
8007
8007
8007
8007
8007
8040
8040
8030
8036
8048
8022
8048
8036
8030
8030
8030
8030
8048
8022
8022
8045
8022
8023
80478023
8023
8047
8047
8024
8046
80468025
8024
8024
8019
8019
8024
8025
8046
8025
8025
8025
8025
8046
8019
8046
8046
8046
8046
8046
8046
8046
8046
80468046
8046
8046
8046
80468046
8046
8019
8040
8022
8040
8040
8040
8022
8022
8008
8008
8008
8008
SUBJECT INDEX
S-lO
MET -NIC
blood pressure
cardiovascular actions
carotid sinus infiltration
CNS stimulants
C-O pressor response
DMPP
efferent sympathetic
transmissionepinephrine
1 evart erenol
nictitating membrane
phentolamine
preganglionic sympathetic
faradi zation
renin
spinal dog
MONOISONITROSOACETONE
DFP-inactivated
ac et yl choline st erase
reactivating action in vivo
MORPHINE
analogs
antipruritic activity
chlorpromazine
cholinesterase activity
emetic action
human subjects
liver microsome system
morphinan compounds
N-demethylation
0-demethylat ion
perphenazine
phospholine
phospholine analog
antagonism
rauwolscine tachypnea
respiratory arrest
MUSCLE ,SKELETAL
ambenonium analogs
circulatory failure
motor facilitation
paralysis
respiratory depression
ryanodine contracture
MUSCLE ,SMOOTH
acetylcholine
bronchiolar resistance
compound 48/80
environmental temperature
epinephrine
hexahydro-l -azepinepropion-
amidoxime
histamine
8024
imidazole-acylcholine esters
1 evarterenol
longitudinal muscle tonusnarcotine
rabbit duodenal strips
rhythmical activity
ryanodine -induced
contracture
spontaneous activity
tachyphylaxi stracheal chain
NARCOTINE
action mechanism
acute toxicity
blood pressure
cardiovascular system
compound 48/80
coronary blood flow
�phenhydramine
femoral blood flow
histamine
histamine liberation
hypotensive action
papaverine
respiration
smooth muscle
species differences
tachyphylaxi sNEUROMUSCULAR FUNCTION
choline esters
NEUROMUSCULAR JUNCTION
acetylcholinesterase
activity
cholinesterase activity
DFP pretreatment
diacetylmonoxime (DAN)
monoisonitrosoacetone (NINA)
phospholine analog (2l7-AO)
phospholine blockade
NICOTINEclonic seizures
localized tremors
salamander
spinal cord transection
8045
8045
8045
8008
8008
8008
8008
8042
8042
8042
8042
8042
8043
8028
8043
8028
8028
8004
8004
8004
8004
8004
8004
8004
8004
8004
8004
8036
8046
8046
8036
8046
NIC -PHE
8033
8033
8032
8037
8034
8008
8034
8034
8008
8008
8034
8008
8048
8048
8048
8048
8015
8035
8035
8015
8035
8009
8009
8009
8034
8034
8022
8022
8022
8022
8014
8014
8014
8014
8014
8014
8014
8014
8014
8014
8014
8014
8032
8037
8015
8037
8033
SUBJECT INDEX
S-ll
1958
NICTITATING MEMBRANE
cervical sympathetic
stimulation
epinephrine injection
rauwol scine
NIKETHAMIDE
athetoid movements
salamander
spinal cord transection
tonic seizures
NORNICOTINE
detoxication
dosage effect
intravenous toxicity
metabolism
urinary excretion
OUABAINhuman erythrocytes
positive inotropic action
potassium transport
temperature
ventricle strips
2,2’ -OXYBIS(�-PHENYLMETHYL-
ENE) BISISOTHIOUREA (BITU)
arterial pressure
cardiovascular actions
DMPP
hexamethoni urn
1 evarterenol
nictitating membrane
plasma histamine levels
potentiating action
vascular resistance
vasomotor reactions
PAPAVERINE
antipruritic activity
coronary blood flow
hemodynamic responses
human subjects
narcotine
PENTOBARBITAL
blood-brain barrier
conditioned avoidance
responses
halogenated hydrocarbons
lipid solubility
liver damage estimation
locomotor activity
post-treatment counts
pretreatment counts
re serpine
sleeping time
PENTYLENETETRAZOLE
anti convul sant s
clonic seizures
8034
CNS antiextensor excitants
reserpine
salamander
spinal cord transection
tonic extensor seizures
tonic seizures
PERPHENAZINE
antiemetic activity
apomorphine-induced emesi s
chlorpromazine
emetic agents
PHENOBARBITAL
blood-brain barrier
human subjects
learning rate
lipid solubility
reaction time
PHENOTHIAZINES
depressant effect
minimal electroshock seizure
threshold
spontaneous motor activity
PHENSUXIMIDE
anticonvulsant activity
reserpine influencePHENTOLAMINE
blood pressure
central respiratory control
cholinesterase activity
phospholine analog (2l7-AO)
PHENYLBUTAZONE NETABOLITES
acute gouty arthritis
antirheumatic action
chloride clearance
electrolyte excretion
inulin clearance
8015 phenylbutazone
phenylbutazone hydroxylation
physiological disposition
plasma levels
plasma protein binding
side reactions
sodium clearance
8014
8014
8014
8014
8022
8022
8022
8022
8022
8022
VOL. 123
8009
8009
8009
8009
8009
8009
8011
8011
8011
8011
8011
8011
8036
8036
8036
8036
8036
8013
8013
8013
80138013
8013
8020
8020
8020
8020
8020
8020
8020
80208020
8020
80208020
8020
8020
8012
8012
8034
8034
8033
8033
8033
8010
8010
8010
8010
8043
8043
8043
8043
8043
8043
8043
SUBJECT INDEX
S-l2
PHE -PYR
sodium-retaining effecturate clearance
uricosuric effectwater excretion
PHOSPHOLINE
anticholinesterase activityblood-brain barrier
morphineneuromuscular transmission
respiration
tertiary analog (2l7-A0)PHOSPHOLINE ANALOG (2l7-AO)
antagonistic action
anticholinesterase activitycentral respiratory control
lipoid solubility
morphine respiratory arrestneuromuscular transmission
PICROTOXIN
anticonvul sant sclonic seizures
8034
CNS antiextensor excitantsreserpine
salamander
spinal cord transectiontonic extensor seizures
tonic seizures
PIPRADOL
antiextensor seizure
activity
CNS stimulants
locomotor responses
post-treatment counts
pretreatment counts
PITUITARY-ADRENAL SYSTEM
acute stress
adrenal ascorbic acid
adrenocorticotrophic
activity
chlorpromazine pretreatment
exogenous ACTH
reserpine pretreatment
POTASSIUM
calcium
erythrocyte transpost
human erythrocytes
inosine response
magnesium
ouabain response
strontium
PROCHLORPERAZINE
MET
spontaneous motor activity
PROMAZINE
MET
spontaneous motor activity
PROMETHAZINE
MET
spontaneous motor activityPROTEIN ,PLASMA
albumin
curarization level
8022 electrophoretic fractions
8022 gamma-globulin
8022 refractory subjects
8022 �-tubocurarine binding8022 properties
8022 PRURITUSexperimental origin
8034 human subjects
8008 morphine treatment
papaverine treatment8034 pathological origin
8034 PURINES
8008 benzimidazoles
8008 competitive metabolite8034 reversal
8008 pyrazolo-(3 ,4d) pyrimidines
quinoxaline s
virus inhibition
virus tissue culture
PYRIDYLACETYLCHOLINE
acetylcholine
blood pressure
cholinesterases
edrophonium
8010 enzyme studies
8010 ganglionic transmission
hexamethonium
hydrolysisimidazoleacetylcholine
neuromuscular transmission
nictitating membranerespiration
succinyldicholine
d- tubocurarine
PYRUVIC ACIDS,
Beta-HALOGENATED
alpha-ketoglutarate
oxidation
analgesia
8012
8012
8012
8012
8012
8012
8012
80128012
8012
80178017
8017
80458045
8045
8045
8045
8045
8045
8045
8045
8045
8035
8035
8035
8035
8035
8029
8029
8029
8029
8029
8014
8014
8014
8014
8014
8014
8034
80328032
80328026
8032
8032
8026
8026
8034
8032
8032
8010
8026
8032
8027
8027
8032
8032
8027
8010
8027
8026
8026
8032
8027
8032
8047
8047
8022
8022
8022
8045
8022
8045
8019
80458022
8042
8045
8022
8022
8022
8022
8045
potentials
rauwol scine
SUBJECT INDEX
S-l3
1958
atropine pretreatmentcholinesterase inhibition
cholinominietic actions
homogenate systems
lacrimation
malate oxidation
pyruvate oxidationsalivation
substrate oxidation
toxic signs
QUATERNARY AIIMONIUM COMPOUNDS
dissociation constant
intestinal absorption
mucosal permeability
RAUWOLSC INK
adrenergic blocking actionblood pressure
cardiovascular system
epinephrineheart rate
hypotensive action
morphine
nictitating membrane
peripheral blood flow
respiration
REACTION TIME
d-amphetamine
human subjects
learning rate
meprobamat e
phenobarbital
REFLEXES
dorsal root stimulation
peroneal nerve stimulation
spinal segmental distributionventral root discharges
zoxazolamine (flexin)RENAL FUNCTION
chloride
clearance studies
inulin
phenylbutazone metabolites
sodium
urate
RESERPINE
acute stress 8010
adrenal ascorbic acid
anticonvul sant s
approach responses
auditory stimuliautonomic nervous systemA-V rhythm
avoidance latency
CAR blockade
cardiac output
cardiovascular effect
8027
CNS stimulants
conditioned avoidance
responses (CAR)
escape response
exogenous ACTHheart -lung preparation
8027
intraventricular injection
levarterenol release
mammalian heartmethamphetamine reversal
pattern discrimination
pentobarbital failure
pituitary adreno-
corticotrophic activity
positive inotropic effect
rate-decreasing effect
S-A rhythm
systemic administration
verat ramine
visual stimuli
RESPIRATION
anesthesia
artificial respiration
atropine pretreatment
central control
cholinesterase activity
cyanide
diaphragmatic contractions
DMPPimidazole-acylcholine esters
morphine influencemorphine-induced arrest
nornicotine metabolism
pentylenetetrazole
phentolamine pretreatment
phospholinephospholine analog (2l7-AO)
phrenic nerve action
PYR-RES
VOL. 123
8047
8047
8045
8047
8025
8025
8047
8025
8025
8047
8047
8047
8025
8025
8025
8025
8025
8047
8047
8025
8025
8047
8025
8047
8025
8025
8025
8047
8047
8025
8025
8047
8047
contracture
8029
8029
8033
8033
8033
8033
8033
8010
8010
8010
8010
8034
8008
8034
8008
80348008
8008
8034
8026
8026
8026
8026
8026
8037
8037
80288028
8028
8037
8037
8037
8037
8047
8047
SUBJECT INDEX
S-14
RES -TET
ryanodine
spastic arrest
tachypneaRYANODINE
acute toxicityATP
atropineblood pressure
caffeine
calcium concentration
cardiac decompensation
cardiac glycosides
circulatory failure
contracture
creatine phosphate
cyanide
dini trophenol
epinephrine
8047
heart -lung preparation
hypotensi onirreversibility
magnesium concentration
mammalian species
papaverinepharmacological actions
procyclidine
pyrilamine
rabbit duodenal strips
respi ration
skeletal muscle
muscle smooth
sodium pyrophosphate
spastic muscle rigidity
vasopressor agents
SALAMANDERbehavior
convulsant drugs
electrical activityneurological tests
neuromuscular system
SEROTONIN
conditioned avoidance
responses
iproniazid
reserpine
SPINAL CORD
motoneurone activity
segmental reflexes
spinal cats
zoxazolamine (flexin)
STATISTICAL EVALUATION
CNS depressantsCNS stimulants
crossover techniques
individual animal
differenceslocomotor responses
STRESS
adrenal ascorbic acid
chlorpromazine
pituitary adreno-
corticotrophic activity
reserpine
STRYCHNINE
anticonvul sants
clonic seizures
8034
CNS antiextensor excitants
reflex arcs
reserpine
salamander
spinal cord transection
tonic extensor seizures
SYMPATHOMIIIETIC AMINES
ephedrine accelerator action
1-epinephrine accelerator
action
heart -lung preparation
heart rate
reserpine antiaccelerator
action
TANNIC ACID
hepatotoxic�.ty8008 pentobarbital sleeping time
8008 TEMPERATURE
8008 ouabain
8008 positive inotropic action
8008 ventricle strips
sym-TETRACHLOROETHANE
hepatotoxicity
8032 lethal potency
8032 TETRACHLOROETHYLENE
8032 hepatotoxicity
lethal potency
8029 ‘�ThAEThYLANMONIUN
8029 ryanodine hypotension
8023
8023
8038
8038
8034
8034
8034
8034
8034
8044
8044
8044
TET-ZOX
80378037
8037
8037
8037
8037
80098009
8036
8036
8011
8011
8011
8011
8011
8015
8015
8015
8015
8015 URICOSURIC AGENTS
phenylbutazone metabolites 8014
8013
8013
8013
8013
8013
8013
8013
8013
8013
8013
8013
8004
8004
8005
8005
8005
80058005
8005
8005
8006
8006
8006
8029
8029
8029
8029
8020
8022
8022
8022
80228020
SUBJECT INDEX
S-l5
1958
TETRAETHYLPYROPHOSPHATE
ambenonium analogs
antidotal pretreatment
atropine-like antidotes
toxicity
TETRAMETHYLSUCCINIMIDE (PM1O9O)
anticonvul santaclonic seizures
CNS antiextensor excitants
reserpine
tonic extensor seizures
THIAZOLIDONE DERIVATIVESirri tancy
local anesthetic activity
systemic toxicity
THIOBARBITAL
blood-brain barrier
lipid solubility
THIOBARBITURATES
brain concentration
brain penetration
hypnotic effects
lipid solubility
plasma concentration
THIOPENTAL
blood-brain barrier
lipid solubility
THIOPHENOBARBITAL
blood-brain barrier
lipid solubility
TISSUE CULTURE ,VIRUS
adenine reversal
adenovi rus
chemical inhibition
cytopathogenic effects
folic acid reversal
growth curves
guanine reversalinfluenza A
inoculation mortality
poliomyelitispurines
TRANSMISSION ,GANGLIONICpyridylacetylcholine
TRANSMISSION ,NEUROMUSCULAR
atropine pretreatmentcholinesterase activity
phospholine
phospholine analog (2l7-AO)pyridylacetylcholine
1,1,1 TRICHLOROETHANE
hepatotoxicity
lethal potency
1,1 ,2-TRICHLOROETHANE
hepatotoxicity
lethal potency
TRICHLOROETHYLENE
hepatotoxicity
lethal potency
TRIFLUOPERAZINE
MET
spontaneous motor activityTRIPELENAMINE
antipruritic activityhuman subjects
d-TUBOCURARINE
8015 curarization level
8015 plasma levels
plasma protein fractions
protein bindingrefractory subjects
8015
8015
8015 VASOMOTOR SYSTEM
8015 BITIJ
hexamethoni um
VASOPRESSOR AGENTS
absolute refractory period
A-V conductionblood pressure
cardiac arrhythmia
cardiac effects
diastolic threshold
tachyphylaxi s
VASOPRESSOR RESPONSES
anesthetized rabbitepinephrine
histamine
ZOXAZOLAMINE
blood pressure
polysynaptic pathways
spinal segmental reflexesventral root discharges
8046
8011
8046
8023
8006
8036
8046
8009
8029
80348044
8015
8033
8022
8032
8046
8043
8038
8018
8023
8041
8014
8008
8018
8037
8005
8008
8040
8046
8019
8028
8028
8017
8022
8039
8041
8011
8033
8036
8013
8030
8018
8009
8033
8017
80158032
80238005
8042
8045
8038
8018
8044
8009
8012
8026
8041
8036
80108030
8049
80158012
8018
8004
80258037
8021
8017
Paasonen N K
Papper E M
8041
8048
8046
8032
8009
8014
8027 Yeager J C
8015 YffTF
1958
AUTHOR INDEX
VOL. 123
Abreu B E
Aladjemoff L
Alexander W N
Arnold A
Banda E
Beecher H K
Begley R W
Benigni J P
‘�ertino J R
Bohner BBorland J K
Brand L
Brodie B B
8014 8015 8017
Brooks C McC
Burns J J
8014 8015
Busch H
Campomanes C I
Cervoni P
Chen G
Clark W C
Daniel A I8007 8039
Dikstein S
Eckhardt E T
Elder C J
Evans E A
Ezz E A
Flanigan J V
Frank M
Fuentes J
Geiger L EGilbert J L
Govier W N8019 8020
Gutman A B
Heidenreich 0 P A
Hendershot L C
Hillyard I WHine C H
Hofstee B H J
Hogben C A M
A-l
Hollinshead A C
Hoppe J 0
8023 8044
Hucker H B
Hulpieu H R
Irwin S
Job C
John K R
Jones W R
Kahn J B Jr
Karczmar A G
Kessler R H
8005 Kirchner F K
Knebel C N
Koelle C B8012 8040 8045
Kornet sky C8015 Krayer 0
8029 8026 8027
8034 Kruck F8016 Kuperman A S
Lands A NLange C
8011 Larson P S
Levy B
8019 Long J P
8009 Lozano R
8037 Luduena F P
8010
Macmullen J A
Macris S G
Mahfouz N
Mannering G J
Maren T H8029 Mark L C
8005 Martin W R
Maxwell R A
8007 8024 8039
8014 Nershon J
8019 8020
Monteleone F
Nair P V
Naranjo P
8013 Paton B C
Peters J J
Pitts R F
8042 Plaa G L
8016 Plummer A J
8007 8024 8039
Polevoy I
Powers T H
Procita L
8025 8047
Rajapurkar N V
Richards A B
Ross S D
8007 8024 8039
Roth F E
Rubin A A
8019 8020
8035 Sanyal P N
Saunders P RSchanker L S
8018 Schaumann W8031 Schneider F
Seifter J
Shafrir ESlabok M
Smith G N
Smith P K
Tabachnick I I A
8019 8020
Takemori A E
Taylor D W
Tedeschi D H
Thomas GTocco D J
Trousof N
Tschirgi R D
Vonderahe A R 8008
Walkenstein S S
8029 Wang S C
Weaver L C8012 Wenzel B N
8006
