Mibelle AG Biochemistry, 5033 Buchs/Switzerland, Phone +41 (0)62 836 13 45, info@mibellebiochemistry.com, www.mibellebiochemistry.com

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Dr. M. Sieber BIONET Corp., Taipei 231, Taiwan Sponsor: Mibelle AG - Biochemistry, 5033 Buchs, Switzerland Test Products • Malus Domestica stem cell extract Cell Line • Umbilical cord derived stem cells

Assays • Growth / Proliferation Test Cells were seeded on 6-well plates (2x104/well). The medium was changed after a first incubation period, the cell number was counted and pictures were taken. • UV Exposure Damage Test Cells were seeded on 96-well plates (5x103/well), the medium was changed after a first incubation period and the cells were exposed to UV radiation afterwards. The MTS assay was performed after 48 hours. Results Malus Domestica stem cell extract shows a promoting effect on stem cell growth. It also shows a protective effect against UV damage.

Effect of PhytoCellTecTM Malus Domestica on Human Stem Cells

Protection of MSC against UV Damage Increase of MSC Cell Growth

Control 0.1% Malus Domesticastem cell extract

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Picture of MSC at 8th day