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AULA6

BioquimicaII

1. Conversodepiruvatoaace7l-CoA:ocomplexopiruvatodesidrogenase

2.Metabolismodoace7l-CoA3. CiclodeKrebs:umcicloanfiblico4.

Asdiferentesetapasderegulao

5. ProduodeATPedeNADH

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Complexopiruvatodesidrogenase

piruvato

NAD+

NADH

ace7l-CoA

CoA

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Ocomplexopiruvatodesidrogenase

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HS

HS

R

S

S

R

R' As O AsR'+

H2O

Regulaodaac;vidadedocomplexoPDH

1. Produto=NADHeace7l-CoA2. Porfosforilao=cinases/fosfatases3. Inibidores:compostoscomarsnio

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ace7l-CoAC2

+

OxaloacetatoC4

CitratoC6

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CICLODEKREBS

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citrato sintetasecitrato sintetase

SINTESEDOCITRATO

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C2

C4C6

C5

C4

CO2

CO2

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C2

C4C6

C5

C4

CO2

CO2

NADH

NADH

NADHFADH2

GTP

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HansKREBS

The Nobel Prize in Physiology or Medicine 1953

for his discovery of the citric acid cycle

"for his discovery of co-enzyme A and itsimportance for intermediary metabolismFritz

Lipmann

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In1937Krebswasabletodemonstratetheexistenceofacycleofchemicalreac7onsthatcombinestheend-product

ofsugarbreakdown,latershowntobeanac7vatedform

ofthetwo-carbonace;cacid,withthefour-carbon

oxaloace;cacidtoformcitricacid.

Thecycleregeneratesoxaloace;cacidwhilelibera7ng

carbondioxideandelectrons

Theelectronsareimmediatelyu7lizedtoformadenosine

triphosphate(ATP).ExtractodeumabiografiadeH.Krebs

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piruvato

citrato

oxaloacetato

1modelodociclodoscidostricarboxlicos

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