Dra. Rosa Anglica Salcedo Hernndez R1 Ciruga Oncolgica4ta semana de gestacin Skandalakis Surgical Anatom!. "c #ra$%Hill. &''4. Ca(. 14.Sadler ). *angman. +m,riologa mdica. -. ed. +ditorial "edica /anamericana. &''1. 0ntestino anterior 1rote tra2ueal Surco tra2ueoeso3agico Alargamiento Sadler ). *angman. +m,riologa mdica. -. ed. +ditorial "edica /anamericana. &''14.. semanaOrringer "5 Heitmiller R. S6ackel3ord. Ciruga del A(arato digesti7o.+s3ago.+ditorial"edica /anamericana.8. ed. &''8."ucosa9 e(itelio cilndrico9 escamoso estrati:cado"usculaturaDos ti(os9estriadalisaCircular*ongitudinalSadler ). *angman. +m,riologa mdica. -. ed. +ditorial "edica /anamericana. &''10rrigacin9 ; ogl ?5 "itc6ell A. #ra!@s Anatom!3or Students &''4. Des7iaciones anatmicasSkandalakis Surgical Anatom!. "c #ra$%Hill. &''4. Ca(. 14Drake R5 >ogl ?5 "itc6ell A. #ra!@s Anatom!3or Students &''4. Di7isin anatmica1. Cer7ical &. )orcica;. A,dominalAACCCABC+R S)A#0B# A)*AS.&''CDrake R5 >ogl ?5 "itc6ell A. #ra!@s Anatom!3or Students &''4. Ca(as del es3agoSkandalakis Surgical Anatom!. "c #ra$%Hill. &''4. Ca(. 14+s3ago cer7icalSkandalakis Surgical Anatom!. "c #ra$%Hill. &''4. Ca(. 14+s3ago torcicoSkandalakis Surgical Anatom!. "c #ra$%Hill. &''4. Ca(. 14+s3ago a,dominal )ra7esa dia3ragmtica;cm en el a,domen ++0Orringer "5 Heitmiller R. S6ackel3ord. Ciruga del A(arato digesti7o.+s3ago.+ditorial"edica /anamericana.8. ed. &''8Drake R5 >ogl ?5 "itc6ell A. #ra!@s Anatom!3or Students &''4. Drena=e 7enoso/*+DO >+BOSO SE1"ECOSO/*+DO /+R0+SOFA#0CO>ena acigos>ena 6emiacigos>ena gstrica iz2uierdaDrake R5 >ogl ?5 "itc6ell A. #ra!@s Anatom!3or Students &''4. Skandalakis Surgical Anatom!. "c #ra$%Hill. &''4. Ca(. 14AACCCABC+R S)A#0B# A)*AS.&''COrringer "5 Heitmiller R. S6ackel3ord. Ciruga del A(arato digesti7o.+s3ago.+ditorial"edica /anamericana.8. ed. &''8B!6us. "aster! o3 Surger!. 8. +d. &''4. >ol. 10ner7acin/aso del alimento deglutido al estomago1. /eristalsis (rimaria&. /eristalsis secundaria;. /eristalsis terciaria+s3nter eso3gico su(erior+s3nter eso3gico in3erior)o$nsend5". Sa,iston )eGt,ook o3 Surger! "c #ra$%Hill.14..ed. &''4. -. cncer mas comita5 >5 *a$rence )5 Rosen,ert S. CABC+R /rinci(les and/ractice o3 Oncolog!. -. ed. *?? &''-..0n3eccionesHelicobacter pyloriCarcinoma clulas escamosas Virus del papiloma humano0nconsistenciaRR ;De>ita5 >5 *a$rence )5 Rosen,ert S. CABC+R /rinci(les and/ractice o3 Oncolog!. -. ed. *?? &''-Iamangar et al. +n7ironmental causes o3 eso(6ageal cancer. #astroenterol Clin B A" ;- K&''ML &4. 84ACA*AS0ARR ;'; a 4O de los (acientes con acalasia14%14 aHos delinicio sintomasLESION POR CAUSICOSSitio de estenosis4'%8' (osterior a la lesin!A"O NIVEL SOCIOECONO#ICORR $ ASOC0ADOS ACA +/0D+R"O0D+Sandler et al. )6e risk o3 eso(6ageal cancer in (atients $it6 ac6alasia. AA"A 1MM8J &449 1;8MDe>ita5 >5 *a$rence )5 Rosen,ert S. CABC+R /rinci(les and/ractice o3 Oncolog!. -. ed. *?? &''-)!losis+n3ermedad autosomica dominanteAnormalidad cromosoma 142&8"aduracin anormal de las clulas escamosasM8O riesgo 4' aHos.S0BDRO"+ D+ /*E""+R% >0BSOB% S0BDRO"+ I+**V1'O desarrollan cncer0rritacin mucosaRAD0AC0OB1' aHos des(us+nzinger. +so(6ageal cancer. B +ngl A "ed &'';J ;4M9 &&41% 8&De>ita5 >5 *a$rence )5 Rosen,ert S. CABC+R /rinci(les and/ractice o3 Oncolog!. -. ed. *?? &''-O1+S0DADAumento incidencia0"C ;'RR ; AdenocarcinomaWXH+RB0A H0A)A*RR ;%C+nzinger. +so(6ageal cancer. B +ngl A "ed &'';J ;4M9 &&41% 8&Iamangar et al. +n7ironmental causes o3 eso(6ageal cancer. #astroenterol Clin B A" ;- K&''ML &4. 84Asociados a adenocarcinomaCarcingenos1. Hidrocar,uros aromticos (oliciclicos&. Com(uestos B% nitrosos KBitrossaminas ! nitrosamidasL;. Acetalde6ido "edicamentosA0B+S Antagonistas H&Rela=acin *+S. De>ita5 >5 *a$rence )5 Rosen,ert S. CABC+R /rinci(les and/ractice o3 Oncolog!. -. ed. *?? &''-Iamangar et al. +n7ironmental causes o3 eso(6ageal cancer. #astroenterol Clin B A" ;- K&''ML &4. 840BCOBS0S)+BC0AAD+BOCARC0BO"A+R#+ RR -ReYu=o se7ero RR &'Asociado con la 3recuencia5 se7eridad ! cronicidad0nduce "eta(lasia*agergren et al. S!ntomatic gastroes(6ageal reYuG as a risk 3actor 3or aso(6ageal adenocarcinoma. B +ngl A "ed. 1MMMJ ;4'.-&8+SOFA#O D+ 1ARR+))"eta(lasia intestinal &91.8%-O de los (acientes con +R#+/o,lacin general '.M R 4.8O)rans3ormacin anual'.8OCook5 ?. As!stematic re7ie$ and metanal!sis o3 t6e seG ratio 3or 1arretts eso(6agus5 erosi7e reYuG disease5 and nonerosi7e reYuG disease. A" = +(idemiol &''8J1C&91'8'RR% 4' % 1&8)res ti(os 9+(itelio cardiaco+(itelio gstrico K3ondoL"eta(lasia intestinal"eta(lasiaDis(lasiaAdenocarcinoma ,a=o R altoCook5 ?. As!stematic re7ie$ and metanal!sis o3 t6e seG ratio 3or 1arretts eso(6agus5 erosi7e reYuG disease5 and nonerosi7e reYuG disease. A" = +(idemiol &''8J1C&91'8'+s3ago de 1arrett 1. *argo K18%&4OL&. CortoKC%-OL4' O asintomtico+ndosco(ia9diagnostica -'O1. +ndosco(ista %+(itelio columnar&. Con:rmacinHisto(atologica ;. De>ita5 >5 *a$rence )5 Rosen,ert S. CABC+R /rinci(les and/ractice o3 Oncolog!. -. ed. *?? &''-Cook5 ?. As!stematic re7ie$ and metanal!sis o3 t6e seG ratio 3or 1arretts eso(6agus5 erosi7e reYuG disease5 and nonerosi7e reYuG disease. A" = +(idemiol &''8J1C&91'8'Carcinoma de clulas escamosas+s3ago normal Dis(lasiaescamosaCncer clulas escamosas +s3ago normal "eta(lasia intestinal Dis(lasia de ,a=o grado Dis(lasia de alto gradoAdenocarcinoma)!losis %Cromosoma14(.De>ita5 >5 *a$rence )5 Rosen,ert S. CABC+R /rinci(les and/ractice o3 Oncolog!. -. ed. *?? &''-

So,reeG(resionFos3orila (R,+7ita e3ecto regulador Altera ciclo celular"olecular 1iolog! o3 +so(6ageal Cancer in t6e #enomics +ra. Surg Clin B Am K&''8LCarcinoma celulas escamosas ( 8;R, (1C+nzinger. +so(6ageal cancer. B +ngl A "ed &'';J ;4M9 &&41% 8&De>ita5 >5 *a$rence )5 Rosen,ert S. CABC+R /rinci(les and/ractice o3 Oncolog!. -. ed. *?? &''-+G(loracin 3sicaAdeno(atas6e(atomegaliaDerrame (leural+so3agograma+stenosis!longitud de la a3eccinBCCB9 O(cionalS+B 1''O+S/ 48OBCCB /ractice #uidelines in Oncolog! &''MOrringer "5 Heitmiller R. S6ackel3ord. Ciruga del A(arato digesti7o.+s3ago.+ditorial"edica /anamericana.8. ed. &''8+SOFA#O#AS)RODEOD+BOSCO/0A+Gtensin de la lesinCaractersticas/ermiterealizar +ES1. )oma de ,io(siaKmnimo CL&. Con:rmacin 6isto(atologcaSensi,ilidad MMO+s(eci:cidad M8OSiersema /. +so(6ageal Cancer.#astroenterol Clin B Am &''-. ;4J M4;%MC4BCCB. /ractice #uidelines in Oncolog! &''ME*)RASOB0DO +BDOSCO/0CO)ransductor de ultrasonido ada(tado al endosco(io/ermite e7aluacin de las (ared eso3agicaAttila5 )5 et al. Role o3 endosco(ic ultrasound in su(er:cial eso(6ageal cancer. Dis o3 +so(6agus.&''MJ&&91'4%11&/ermite7isualizar el grado de in:ltracin del tumor.+stadi:cacin mas eGacta. Sen -' al M'OAttila5 )5 et al. Role o3 endosco(ic ultrasound in su(er:cial eso(6ageal cancer. Dis o3 +so(6agus.&''MJ&&91'4%11&1ri=,assie A5 et al. +so(6ageal Cancer9 Eltrasonogra(6!. #astroenterol Clin BAm. &''M.;-J M;%1'-/ermite e7aluacin ganglionar KBL 9 FBACon:rmacin 6istolgicaSen -'O+s( 4'O+ES%FBA Sen M&O +s( M&OAttila5 )5 et al. Role o3 endosco(ic ultrasound in su(er:cial eso(6ageal cancer. Dis o3 +so(6agus.&''MJ&&91'4%11&1ri=,assie A5 et al. +so(6ageal Cancer9 Eltrasonogra(6!. #astroenterol Clin BAm. &''M.;-J M;%1'-De:nir la (resencia de ganglios celiacos o metstasis 6e(ticas#anglios celiacos K &cm del tronco celiacoLSen C4.&O5 +s( M-.1O.Attila5 )5 et al. Role o3 endosco(ic ultrasound in su(er:cial eso(6ageal cancer. Dis o3 +so(6agus.&''MJ&&91'4%11&1ri=,assie A5 et al. +so(6ageal Cancer9 Eltrasonogra(6!. #astroenterol Clin BAm. &''M.;-J M;%1'-8'O mas eGacto en la e7aluacin ) ! BDetermina la en3ermedad localBCCB9 A,orda=e diagnostico ! estadi:cacin+S"O9 0ndica estadi:cacin (reo(eratoria*imitaciones9 de(ende o(eradorBCCB &''M+S"O "inimal Clinical Recommendatins 3or diagnosis5treatment and 3ollo$%u( o3 eso(6ageal cancer. Annals o3 oncolog! 1CKsu((l 1M9 i&C%i&45&''8)omogra3a com(utada/redictor (ronostico%0n:ltracin localK 4M R C'OLN8mm%A3eccin ganglionar %Z1cm%Sensi,ilidad;'%C' O%+s(eci:cidad C' R -'O Iorst R5 et al. 0maging 3or +so(6ageal )umors. Radiol Clin B Am &''8J4;9 C11 R C1MBCCB /ractice #uidelines in Oncolog!. &''M)omogra3a com(utada % #anglios (erieso3agicosK -; R -4OL%#anglios mediastino K81 R 4' OLIorst R5 et al. 0maging 3or +so(6ageal )umors. Radiol Clin B Am &''8J4;9 C11 R C1M/atel et al. Current Staging o3 +so(6ageal Carcinoma. Surg Clin B Am &''8.J-89888%8C4"etstasis&'O a la (resentacinHgado5 (ulmn5 glndula Su(rarrenal1 cmSensi,ilidad -;O+s(eci:cidad 48OPOCO UILRESPUESAA RAA#IENOIorst R5 et al. 0maging 3or +so(6ageal )umors. Radiol Clin B Am &''8J4;9 C11 R C1M/atel et al. Current Staging o3 +so(6ageal Carcinoma. Surg Clin B Am &''8.J-89888%8C4R+SOBABC0A "A#B+)0CADelinear mrgenes entre estructuras ad!acentesO,ser7ar di7ersos (lanosSensi,ilidad 1''O +s(eci:cidad M8.8OBo sustitu!e )ACBo indica BCCB/atel et al. Current Staging o3 +so(6ageal Carcinoma. Surg Clin B Am &''8.J-89888%8C4)AC9 Detectar metstasisSens 41%-1O5 +s( -&%-;OES# endosco(ico K)5 Adeno(atasLsens 11%84O5 es(eci:cidad M'%M8OFD#%/+)"ide (roceso meta,licoRadio trazador emite (ositrones T FD#Voon H5 et al. )6e role o3 FD#%/+) and Staging *a(arosco(! in t6e "anagement o3 /atients $it6 Cancer o3 t6e +so(6agus or #astroeso(6ageal Aunction. #astroenterol Clin B Am&''M.;-. 1'8%1&'S$is6er et al. Etilit! o3 /+)5 C)5 and +ES to identi3! (at6ologic res(onders in eso(6ageal cancer. Ann )6orac Surg &''4J 4-9 118&% C'/+)Poca utilidad para determinar %Detectar tumores (rimarios K M1%M8OL*imitada resolucin es(acialLimitado uso en e&aluaci'n(an(lios lin)*ticos locore(ionalesSensi,ilidad! es(eci:cidad 81O ! -4OE&aluaren)ermedad metast*sica% &'O la (resenta Voon H5 et al. )6e role o3 FD#%/+) and Staging *a(arosco(! in t6e "anagement o3 /atients $it6 Cancer o3 t6e +so(6agus or #astroeso(6ageal Aunction. #astroenterol Clin B Am&''M.;-. 1'8%1&'*imitacionesFalsos (ositi7osCostoAccesi,ilidadO+ASLAS LESIONES SOSPECHOSAS +E!EN SER CON,IR#A+AS*ig6tdaleC/ositron +misssion )omogra(6!9 Anot6er Ese3ul )est 3or Staging +so(6ageal Cancer.A Clinic Oncol &''' 1-K1-L;1MM%;&'1BCCB9/+)QC)5 7s /+)9 Si no 6a! e7idencia de "1.+S"O9 Bo lo mencionaBCCB &''M+S"O "inimal Clinical Recommendatins 3or diagnosis5treatment and 3ollo$%u( o3 eso(6ageal cancer. Annals o3 oncolog! 1CKsu((l 1M9 i&C%i&45&''81roncosco(a9 tumor arri,a Carina*a(arosco(ia 1. BCCB9 o(cional&. )umores de la unin gastroes3ogicaSi no 6a! e7idencia "1 /ractice #uidelines in Oncolog!. BCCB &''M*uketic6 et al. "inimall! in7asi7e surgical staging in su(erior to endosco(ic ultrasound in detecting l!m(6 node metastasis in eso(6ageal cancer. A )6orac Cardio7asc Surg 1MM4J 1149-14AACC)umor (rimario K)L)G. +l tumor (rimario no (uede ser e7aluado)'. Bo 6a! e7idencia de tumor (rimario)is. Carcinoma in situ)1. )umor in7ade lamina (ro(ia o su,mucosaAACCCABC+R S)A#0B# A)*AS.&''C)&. )umor 2ue in7ade la muscularis (ro(iaAACCCABC+R S)A#0B# A)*AS.&''C);. )umor 2ue in7ade la ad7enticiaAACCCABC+R S)A#0B# A)*AS.&''C)4. )umor 2ue in7ade estructuras ad!acentes#anglios lin3ticos regionales KBLBG. *os ganglios no (ueden ser e7aluadosB'. Bo 6a! metstasis a ganglios lin3ticos regionalesB1. "etstasis a ganglios lin3ticos regionalesAACCCABC+R S)A#0B# A)*AS.&''CAACCCABC+R S)A#0B# A)*AS.&''CAACCCABC+R S)A#0B# A)*AS.&''C.#et*stasis a distancia -#."G "etstasis a distancia no (ueden ser e7aluados"'. Bo 6a! metstasis a distancia"1. "etstasis a distancia. )umores de el es3ago torcico in3erior"1a. "etstasis a nodos lin3ticos celiacos. "1,. Otras metstasis a distancia. )umores del es3ago torcico medio"1a. Bo a(lica,le"1,. Bodos lin3ticos no regionales ! otras metstasis a distancia. )umores del es3ago torcico su(erior"1a. "etstasis a nodos cer7icales"1,. Otras metstasis a distanciaAACCCABC+R S)A#0B# A)*AS.&''C8' O tienen a3eccin locoregionalN C'O (ueden ser sometidos a reseccin curati7a4'%-'O resecciones tienen a3eccin de ganglios regionalesBCCB /ractice #uidelines in Oncolog! &''M)i(o 0)i(o 00)i(o 000Sie$ert5 R. Adenocarcinoma o3 t6e eso(6agogastric =unction. Ann Surg. &'''.&;&J ;8;%;C1+stadioEstadio I/0 1 203+stadio 00A;' R 4'O+stadio 001 1' R ;' O+stadio 000 1' R 18O+stadio 0> N 1 aHo+nzinger5 et al.B +ngl "ed &'';J;4M9&&41%8&Sung%*ing C5 et al. /rognostic >aria,les in )6oracic +so(6ageal S2uamous Cell Carcinoma. Ann )6orac Surg &''MJ-49 1'8C % C8/ro3undidad del tumorK'O5 14O5 84OL)amaHo del tumorN 1' mm-O11 R &' mm&'O&1% ;'mm;;O;1% 4'mm&;O41 %8' mm 8'OZ8' mm44OS6imada H5 /rediction o3 *!m(6 node status in (atients $it6 su(er:cial eso(6ageal carcinoma9 anal!sis o3 1C' surgicall! resected cancers. Am A Surg. &''C91M1J &8' % &84"etstasis lin3tica B'4'OSo,re7ida glo,al 14OB1;O)amaHo del ganglioNMmm K-1OLZ1'mm K;'OLBumero de ganglios+nzinger5 et al.B +ngl "ed &'';J;4M9&&41%8&Sung%*ing C5 et al. /rognostic >aria,les in )6oracic +so(6ageal S2uamous Cell Carcinoma. Ann )6orac Surg &''MJ-49 1'8C % C8/erdida de (eso Z 1' kgDis3agia+dad a7anzada"icrometastasis +nzinger5 et al.B +ngl "ed &'';J;4M9&&41%8&Sung%*ing C5 et al. /rognostic >aria,les in )6oracic +so(6ageal S2uamous Cell Carcinoma. Ann )6orac Surg &''MJ-49 1'8C % C8Carcinoma clulas escamosas T +E 1. /acientes cncer oro3aringeo &. )!losis Adenocarcinoma1. +R#+ se7ero K4'O asintomticoL&. Factores de riesgo ;. +s3ago de 1arret )omiza$a V5 et al. Screening5 Sur7eillance5 and /re7ention 3or+so(6ageal Cancer.#astroenterol Clin B Am &''MJ;-9 8M%4;0nadomi ". Screening and Sur7eillance 3or 1arrett +so(6agus in Hig6 Risk #rou(s9 A Cost%Etilit! Anal!sis. Ann 0ntern"ed. &'';J1;-914C%1-C+ndosco(ia1a=o 7alor (redicti7o negati7oCostoDe(endeo(erador+ndosco(ia de cali,re (e2ueHo+ndosco(ia transnasal

)omiza$a V5 et al. Screening5 Sur7eillance5 and /re7ention 3or+so(6ageal Cancer.#astroenterol Clin B Am &''MJ;-9 8M%4;0magen autoYuorescencia/acientes alto riesgo9 costo [&454'' /acientes con +R#+ Z8' aHos9 1'544'0nconsistencia )omiza$a V5 et al. Screening5 Sur7eillance5 and /re7ention 3or+so(6ageal Cancer.#astroenterol Clin B Am &''MJ;-9 8M%4;)omiza$a V5 et al. Screening5 Sur7eillance5 and /re7ention 3or+so(6ageal Cancer.#astroenterol Clin B Am &''MJ;-9 8M%4;Inter&alo de &i(ilanciaDis(lasiaDocumentacin Seguimiento Bo& endosco(ias con ,io(sia en 1 aHo+ndosco(ia cada ; aHos1a=o grado +ndosco(ia cada C mesesCada aHo des(us de dos negati7asAlto grado +ndosco(ia con ,io(sia 2ue eGclu!a adenocarcinoma cada ; meses Continuar cada ; meses o inter7enir de(endiendo el casoDurante el (rimer aHo%Cada 4 meses%Cada C meses los siguientes dos aHos%V (osteriormente anual1. *a,oratorios KC mesesL/ractice #uidelines in Oncolog!. &''M BCCB+ndosco(ia )ac de traG ! a,domen su(erior 0ndi7idualiza. ABEA*#RAC0AS